ArticleProceedings of the National Academy of Sciences of the United States of America2000
Restriction of ectopic recombination by interhomolog interactions during Saccharomyces cerevisiae meiosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Article
- Recent advances in mechanisms ensuring the pairing, synapsis and segregation of XY chromosomes in mice and humans.Cellular and molecular life sciences : CMLS · 2024Review
- Blessing or curse: how the epigenetic resolution of host-transposable element conflicts shapes their evolutionary dynamics.Proceedings. Biological sciences · 2024Article
- Article
- Meiosis in budding yeast.Genetics · 2023Article
- The different subtelomeric structure among 1RS arms in wheat-rye 1BL.1RS translocations affecting their meiotic recombination and inducing their structural variation.BMC genomics · 2023Article
- Meiotic cells escape prolonged spindle checkpoint activity through kinetochore silencing and slippage.PLoS genetics · 2023Article
- Heterologous synapsis in C. elegans is regulated by meiotic double-strand breaks and crossovers.Chromosoma · 2021Article
- Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation.Genes & development · 2020Article
- Coevolution between transposable elements and recombination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Article
- Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice.Cell cycle (Georgetown, Tex.) · 2017Article
- Meiotic Chromosome Association 1 Interacts with TOP3α and Regulates Meiotic Recombination in Rice.The Plant cell · 2017Article
- Cytological basis of sterility in male and female hybrids between sibling species of grey voles Microtus arvalis and M. levis.Scientific reports · 2016Article
- A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions.PLoS genetics · 2016Article
- OsDMC1 Is Not Required for Homologous Pairing in Rice Meiosis.Plant physiology · 2016Article
- X marks the spot: PRDM9 rescues hybrid sterility by finding hidden treasure in the genome.Nature structural & molecular biology · 2016Article
- Recombination, Pairing, and Synapsis of Homologs during Meiosis.Cold Spring Harbor perspectives in biology · 2015Review
- Global Identification of Genes Specific for Rice Meiosis.PloS one · 2015Article
- OsHUS1 facilitates accurate meiotic recombination in rice.PLoS genetics · 2014Article
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2 authors.
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Abstract
In Saccharomyces cerevisiae meiosis, recombination occurs frequently between sequences at the same location on homologs (allelic recombination) and can take place between dispersed homologous sequences (ectopic recombination). Ectopic recombination occurs less often than does allelic, especially when homologous sequences are on heterologous chromosomes. To account for this, it has been suggested that homolog pairing (homolog colocalization and alignment) either promotes allelic recombination or restricts ectopic recombination. The latter suggestion was tested by examining ectopic recombination in two cases where normal interhomolog relationships are disrupted. In the first case, one member of a homolog pair was replaced by a homologous (related but not identical) chromosome that has diverged sufficiently to prevent allelic recombination. In the second case, ndj1 mutants were used to delay homolog pairing and synapsis. Both circumstances resulted in a substantial increase in the frequency of ectopic recombination between arg4-containing plasmid inserts located on heterologous chromosomes. These findings suggest that, during normal yeast meiosis, progressive homolog colocalization, alignment, synapsis, and allelic recombination restrict the ability of ectopically located sequences to find each other and recombine. In the absence of such restrictions, the meiotic homology search may encompass the entire genome.
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