ArticleThe EMBO journal2000
ACAULIS5, an Arabidopsis gene required for stem elongation, encodes a spermine synthase.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 274 citations in OpenAlex.
- Integrated Transcriptomic and Phytohormone Metabolomic Analyses Reveal Distinct Molecular States Associated with PSTVd-Induced Potato Tuber Cracking and Knob-like Protuberances at Tuber Eyes.Plants (Basel, Switzerland) · 2026Article
- Decoding a polyamine signal to direct vascular fate: thermospermine meets the ribosome.Journal of experimental botany · 2026Article
- Dual functions of thermospermine in plant growth and stress responses.Amino acids · 2026Review
- PagSAMDC4a-Mediated Polyamine Synthesis Regulate Vessel Differentiation Under Drought Stress Conditions in Poplar.Plant biotechnology journal · 2025Article
- RNA processing/modifying enzymes play key roles in the response to thermospermine in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2025Article
- Thermospermine Is an Evolutionarily Ancestral Phytohormone Required for Organ Development and Stress Responses in Marchantia Polymorpha.Plant & cell physiology · 2024Article
- Comparative Transcriptome Sequencing and Endogenous Phytohormone Content of Annual Grafted Branches ofInternational journal of molecular sciences · 2023Article
- Suppression of the dwarf phenotype of an Arabidopsis mutant defective in thermospermine biosynthesis by a synonymous codon change in the SAC51 uORF.Molecular genetics and genomics : MGG · 2023Article
- Characterization and fine mapping analysis of a major stable QTL qKnps-4A for kernel number per spike in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Plant Peroxisomal Polyamine Oxidase: A Ubiquitous Enzyme Involved in Abiotic Stress Tolerance.Plants (Basel, Switzerland) · 2023Review
- The spinach YY genome reveals sex chromosome evolution, domestication, and introgression history of the species.Genome biology · 2022Article
- Effect of thermospermine on expression profiling of different gene using massive analysis of cDNA ends (MACE) and vascular maintenance in Arabidopsis.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Nitrogen and Stem Development: A Puzzle Still to Be Solved.Frontiers in plant science · 2021Review
- Spermidine Is Critical for Growth, Development, Environmental Adaptation, and Virulence inFrontiers in microbiology · 2021Article
- Citrus Polyamines: Structure, Biosynthesis, and Physiological Functions.Plants (Basel, Switzerland) · 2020Review
- ACAULIS5 Is Required for Cytokinin Accumulation and Function During Secondary Growth ofFrontiers in plant science · 2020Article
- Effect of Thermospermine on the Growth and Expression of Polyamine-Related Genes in Rice Seedlings.Plants (Basel, Switzerland) · 2019Article
- Article
- Polyamine Action under Metal/Metalloid Stress: Regulation of Biosynthesis, Metabolism, and Molecular Interactions.International journal of molecular sciences · 2019Review
- Polyamine Oxidases Play Various Roles in Plant Development and Abiotic Stress Tolerance.Plants (Basel, Switzerland) · 2019Review
22 more citing papers are in PubMed but not listed here.
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Polyamines have been implicated in a wide range of biological processes, including growth and development in bacteria and animals, but their function in higher plants is unclear. Here we show that the Arabidopsis: ACAULIS5 (ACL5) gene, whose inactivation causes a defect in the elongation of stem internodes by reducing cell expansion, encodes a protein that shares sequence similarity with the polyamine biosynthetic enzymes spermidine synthase and spermine synthase. Expression of the recombinant ACL5 protein in Escherichia coli showed that ACL5 possesses spermine synthase activity. Restoration of the acl5 mutant phenotype by somatic reversion of a transposon-induced allele suggests a non-cell-autonomous function for the ACL5 gene product. We also found that expression of the ACL5 cDNA under the control of a heat shock gene promoter in acl5 mutant plants restores the phenotype in a heat shock-dependent manner. The results of the experiments showed that polyamines play an essential role in promotion of internode elongation through cell expansion in Arabidopsis: We discuss the relationships to plant growth regulators such as auxin and gibberellins that have related functions.
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