ReviewMicroscopy research and technique2000
Mesopic state: cellular mechanisms involved in pre- and post-synaptic mixing of rod and cone signals.
Review in Microscopy research and technique, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Pupillary Light Reflex Reveals Melanopsin System Alteration in the Background of Myopia-26, the Female Limited Form of Early-Onset High Myopia.Investigative ophthalmology & visual science · 2024Article
- Effects of D-serine treatment on outer retinal function.Experimental eye research · 2021Article
- Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis.Investigative ophthalmology & visual science · 2020Article
- Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells.Frontiers in cellular neuroscience · 2020Article
- Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina.Scientific reports · 2017Article
- Disruption in dopaminergic innervation during photoreceptor degeneration.The Journal of comparative neurology · 2016Article
- Light-evoked S-nitrosylation in the retina.The Journal of comparative neurology · 2015Article
- Role of dopamine in distal retina.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Review
- Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Adenosine and dopamine receptors coregulate photoreceptor coupling via gap junction phosphorylation in mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Blurring the boundaries of vision: novel functions of intrinsically photosensitive retinal ganglion cells.Journal of experimental neuroscience · 2013Review
- Paired-pulse plasticity in the strength and latency of light-evoked lateral inhibition to retinal bipolar cell terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Light-evoked lateral GABAergic inhibition at single bipolar cell synaptic terminals is driven by distinct retinal microcircuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Circadian regulation of ion channels and their functions.Journal of neurochemistry · 2009Review
- Circadian phase-dependent modulation of cGMP-gated channels of cone photoreceptors by dopamine and D2 agonist.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Calcium regulation in photoreceptors.Frontiers in bioscience : a journal and virtual library · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
At least twice daily our retinas move between a light adapted, cone-dominated (photopic) state and a dark-adapted, color-blind and highly light-sensitive rod-dominated (scotopic) state. In between is a rather ill-defined transitional state called the mesopic state in which retinal circuits express both rod and cone signals. The mesopic state is characterized by its dynamic and fluid nature: the rod and cone signals flowing through retinal networks are continually changing. Consequently, in the mesopic state the retinal output to the brain contained in the firing patterns of the ganglion cells consists of information derived from both rod and cone signals. Morphology, physiology, and psychophysics all contributed to an understanding that the two systems are not independent but interact extensively via both pooling and mutual inhibition. This review lays down a rationale for such rod-cone interactions in the vertebrate retinas. It suggests that the important functional role of rod-cone interactions is that they shorten the duration of the mesopic state. As a result, the retina is maintained in either in the (rod-dominated) high sensitivity photon counting mode or in the second mode, which emphasizes temporal transients and spatial resolution (the cone-dominated photopic state). Experimental evidence for pre- and postsynaptic mixing of rod and cone signals in the retina of the clawed frog, Xenopus, is shown together with the preeminent neuromodulatory role of both light and dopamine in controlling interactions between rod and cone signals. Dopamine is shown to be both necessary and sufficient to mediate light adaptation in the amphibian retina.
Indexed as
Identifiers
10941171PMC2954776W2096521333What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.