Evidence map›Paper›PMID 10940279›Full record

ArticleGut2000

A reproducible grading scale for histological assessment of inflammation in ulcerative colitis.

K Geboes, R Riddell, A Ost, B Jensfelt, T Persson, R Löfberg

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 376 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
376citing papers in PubMed, 6 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01852760 completednot on this mapstarted 2013, after this paper: background citation

Assessment of Disease Activity in Ulcerative Colitis by Endoscopic Ultrasound

TypeobservationalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2013 to 2015Enrolled60ConditionsUlcerative Colitis, Inflammatory Bowel Disease
NCT03000101 nacompletednot on this mapstarted 2017, after this paper: background citation

New Insight and Knowledge on Anti-inflammatory Effectiveness of Dietary Phenolics (NIKE)

TypeinterventionalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2017 to 2023Enrolled18ConditionsCrohn's Disease, Ulcerative ColitisArms100% pomegranate juice, placebo beverage
3 · Its place in the literature

Who cites it

376 citing papers in PubMed, 6 syntheses or guidelines pooled it, 926 citations in OpenAlex.

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  19. Modeling Endoscopic Improvement after Induction Treatment With Mesalamine in Patients With Mild-to-Moderate Ulcerative Colitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
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316 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

K GeboesGI pathology Unit, KU Leuven, Belgium. Karel.Geboes@uz.kuleuven.ac.be
R Riddell
A Ost
B Jensfelt
T Persson
R Löfberg
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvaluation of histological activity in ulcerative colitis needs to be reproducible but has rarely been tested. This could be useful both clinically and in clinical trials.

aimTo develop reproducible criteria which are valid in the assessment of acute inflammation (activity) and chronicity, and to evaluate these features in an interobserver variability study.

methodsA six grade classification system for inflammation was developed which could also be fine tuned within each grade. The grades were: 0, structural change only; 1, chronic inflammation; 2, lamina propria neutrophils; 3, neutrophils in epithelium; 4, crypt destruction; and 5, erosions or ulcers. Ninety nine haematoxylin-eosin sections from endoscopically inflamed and non-inflamed mucosa from patients with distal ulcerative colitis were assessed in two separate readings by three pathologists independently and without knowledge of the clinical status. Interobserver agreement was compared pairwise using kappa statistics.

resultsInitially, kappa values between the observers were 0.20, 0.42, and 0.26, which are too low to be of value. Following development of a semiquantitative pictorial scale for each criterion, kappa values improved to 0.62, 0.70, and 0.59. For activity defined by neutrophils between epithelial cells, kappa values were 0.903, 1.000, and 0.907. Complete agreement was reached in 64% of samples of endoscopically normal and in 66% of endoscopically inflamed tissue. Neutrophils in epithelium correlated with the presence of crypt destruction and ulceration.

conclusionA histological activity system was developed for ulcerative colitis that showed good reproducibility and modest agreement with the endoscopic grading system which it complemented. It has potential value both clinically and in clinical trials.

Indexed as

BiopsyColitis, UlcerativeHumansObserver VariationReproducibility of ResultsSeverity of Illness Index

Identifiers

PMID10940279
PMCPMC1728046
OpenAlexW2116318925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.