ArticleMolecular and cellular biology2000
Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 104 citations in OpenAlex.
- Signalling through RXRβ and its agonist, bexarotene, promotes neuron formation in Xenopus laevis embryos.Biology open · 2026Article
- Hindbrain induction and patterning during early vertebrate development.Cellular and molecular life sciences : CMLS · 2019Review
- TCF/Lef regulates the Gsx ParaHox gene in central nervous system development in chordates.BMC evolutionary biology · 2016Article
- CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition.Developmental biology · 2016Article
- Analysis of dynamic changes in retinoid-induced transcription and epigenetic profiles of murine Hox clusters in ES cells.Genome research · 2015Article
- The gene regulatory networks underlying formation of the auditory hindbrain.Cellular and molecular life sciences : CMLS · 2015Review
- SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation.Molecular cell · 2014Article
- RAGE, receptor of advanced glycation endoproducts, negatively regulates chondrocytes differentiation.PloS one · 2014Article
- YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.PloS one · 2014Article
- Chiari malformation type I: a case-control association study of 58 developmental genes.PloS one · 2013Article
- Article
- Caudal genes in blood development and leukemia.Annals of the New York Academy of Sciences · 2012Review
- Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer.The Journal of biological chemistry · 2012Article
- Vertebrate intestinal endoderm development.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- FGF signalling: diverse roles during early vertebrate embryogenesis.Development (Cambridge, England) · 2010Review
- MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.World journal of gastroenterology · 2010Article
- Signaling gradients during paraxial mesoderm development.Cold Spring Harbor perspectives in biology · 2010Review
- Article
- Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis.PloS one · 2009Article
- Function of retinoic acid receptors during embryonic development.Nuclear receptor signaling · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinoic acid (RA) is required for diverse developmental programs, including vertebral specification. Both RA receptor disruption and excess RA result in homeotic transformations of the axial skeleton. These effects are believed to occur through altered expression of Hox genes, several of which have been demonstrated to be direct RA targets. Members of the cdx (caudal) homeobox gene family are also implicated in regulating Hox expression. Disruption of cdx1 results in vertebral homeotic transformations and alteration of Hox expression boundaries; similar homeosis is also observed in cdx2 heterozygotes. In Xenopus, gain or loss of Cdx function affects vertebral morphogenesis through a mechanism that also correlates with altered Hox expression. Taken together with the finding of putative Cdx binding motifs in several Hox promoters, these data strongly support a role for Cdx members in direct regulation of expression of at least some Hox genes. Most retinoid-responsive Hox genes have not been demonstrated to be direct RA targets, suggesting that intermediaries are involved. Based on these findings, we hypothesized that one or more cdx members may transduce the effects of RA on Hox transcription. Consistent with this, we present evidence that cdx1 is a direct RA target gene, suggesting an additional pathway for retinoid-dependent vertebral specification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.