ArticleMolecular and cellular biology2000
Structure and dynamic properties of a glucocorticoid receptor-induced chromatin transition.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 91 citations in OpenAlex.
- Pioneering new enhancers by GATA3: role of facilitating transcription factors and chromatin remodeling.Nucleic acids research · 2025Article
- RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation.Scientific reports · 2023Article
- Article
- Impact of chromatin structure on PR signaling: transition from local to global analysis.Molecular and cellular endocrinology · 2012Review
- Control of nuclear receptor function by local chromatin structure.The FEBS journal · 2011Review
- The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its coregulatory molecules CBP/p300 during ultradian ligand treatment.Molecular endocrinology (Baltimore, Md.) · 2011Article
- ICM Web: the interactive chromatin modeling web server.Nucleic acids research · 2010Article
- Divergent human remodeling complexes remove nucleosomes from strong positioning sequences.Nucleic acids research · 2010Article
- Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.The Journal of biological chemistry · 2009Article
- Article
- Glucocorticoid receptor dynamics and gene regulation.Stress (Amsterdam, Netherlands) · 2009Review
- A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Dynamic access of the glucocorticoid receptor to response elements in chromatin.The international journal of biochemistry & cell biology · 2009Review
- Dynamic protein associations define two phases of IL-1beta transcriptional activation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Sequence-dependent variations associated with H2A/H2B depletion of nucleosomes.Biophysical journal · 2008Article
- Chromatin-dependent cooperativity between site-specific transcription factors in vivo.The Journal of biological chemistry · 2007Article
- Two-component atomic force microscopy recognition imaging of complex samples.Analytical biochemistry · 2007Article
- Organization of interphase chromatin.Chromosoma · 2006Review
- Chromatin dynamics and the evolution of alternate promoter states.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- Solution AFM studies of human Swi-Snf and its interactions with MMTV DNA and chromatin.Biophysical journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Activation of the mouse mammary tumor virus (MMTV) promoter by the glucocorticoid receptor (GR) is associated with a chromatin structural transition in the B nucleosome region of the viral long terminal repeat (LTR). Recent evidence indicates that this transition extends upstream of the B nucleosome, encompassing a region larger than a single nucleosome (G. Fragoso, W. D. Pennie, S. John, and G. L. Hager, Mol. Cell. Biol. 18:3633-3644). We have reconstituted MMTV LTR DNA into a polynucleosome array using Drosophila embryo extracts. We show binding of purified GR to specific GR elements within a large, multinucleosome array and describe a GR-induced nucleoprotein transition that is dependent on ATP and a HeLa nuclear extract. Previously uncharacterized GR binding sites in the upstream C nucleosome region are involved in the extended region of chromatin remodeling. We also show that GR-dependent chromatin remodeling is a multistep process; in the absence of ATP, GR binds to multiple sites on the chromatin array and prevents restriction enzyme access to recognition sites. Upon addition of ATP, GR induces remodeling and a large increase in access to enzymes sites within the transition region. These findings suggest a dynamic model in which GR first binds to chromatin after ligand activation, recruits a remodeling activity, and is then lost from the template. This model is consistent with the recent description of a "hit-and-run" mechanism for GR action in living cells (J. G. McNally, W. G. Müller, D. Walker, and G. L. Hager, Science 287:1262-1264, 2000).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.