ArticleMolecular and cellular biology2000
Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Structural Aspects of DNA Repair and Recombination in Crop Improvement.Frontiers in genetics · 2020Review
- The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans.Fungal genetics and biology : FG & B · 2011Article
- Sgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae.Journal of molecular biology · 2011Article
- The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance.PloS one · 2010Article
- The RecQ DNA helicases in DNA repair.Annual review of genetics · 2010Review
- Role of Blm and collaborating factors in recombination and survival following replication stress in Ustilago maydis.DNA repair · 2009Article
- Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.The EMBO journal · 2009Article
- The Arabidopsis BLAP75/Rmi1 homologue plays crucial roles in meiotic double-strand break repair.PLoS genetics · 2008Article
- Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.The Journal of cell biology · 2008Article
- Article
- Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover.The EMBO journal · 2006Article
- Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.Molecular and cellular biology · 2006Article
- Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex.Molecular and cellular biology · 2005Article
- RecQ helicases: suppressors of tumorigenesis and premature aging.The Biochemical journal · 2003Review
- Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation.Molecular and cellular biology · 2003Article
- SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases.Nucleic acids research · 2002Article
- Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint.Molecular and cellular biology · 2001Article
- A yeast gene, MGS1, encoding a DNA-dependent AAA(+) ATPase is required to maintain genome stability.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SGS1 gene of Saccharomyces cerevisiae is a homologue for the Bloom's syndrome and Werner's syndrome genes. The disruption of the SGS1 gene resulted in very poor sporulation, and the majority of the cells were arrested at the mononucleated stage. The recombination frequency measured by a return-to-growth assay was reduced considerably in sgs1 disruptants. However, double-strand break formation, which is a key event in the initiation of meiotic DNA recombination, occurred; crossover and noncrossover products were observed in the disruptants, although the amounts of these products were slightly decreased compared with those in wild-type cells. The spores produced by sgs1 disruptants showed relatively high viability. The sgs1 spo13 double disruptants sporulated poorly, like the sgs1 disruptants, but spore viability was reduced much more than with either sgs1 or spo13 single disruptants. Disruption of the RED1 or RAD17 gene partially alleviated the poor-sporulation phenotype of sgs1 disruptants, indicating that portions of the population of sgs1 disruptants are blocked by the meiotic checkpoint. The poor sporulation of sgs1 disruptants was complemented with a mutated SGS1 gene encoding a protein lacking DNA helicase activity; however, the mutated gene could suppress neither the sensitivity of sgs1 disruptants to methyl methanesulfonate and hydroxyurea nor the mitotic hyperrecombination phenotype of sgs1 disruptants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.