ArticleMolecular and cellular biology2000
Replication of heterochromatin and structure of polytene chromosomes.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 70 citations in OpenAlex.
- A chromosome-level genome assembly of Vanilla planifolia uncovers the genomic architecture underlying partial endoreplication.BMC genomics · 2026Article
- Cell cycle variants during Drosophila male accessory gland development.G3 (Bethesda, Md.) · 2024Article
- Chromosomal polymorphisms have no negative effect on reproductive outcomes after IVF/ICSI-ET/FET.Scientific reports · 2022Article
- Cyclin E overexpression in theFrontiers in cell and developmental biology · 2022Article
- Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males.Nature communications · 2020Article
- Comparative Cytology of Female Meiosis I AmongG3 (Bethesda, Md.) · 2020Article
- Genome Size Reversely Correlates With Host Plant Range inFrontiers in physiology · 2019Article
- Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication inGenes & development · 2017Article
- The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population.Journal of assisted reproduction and genetics · 2016Article
- Chromosomal Replication Complexity: A Novel DNA Metrics and Genome Instability Factor.PLoS genetics · 2016Review
- Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2.Journal of cell science · 2016Article
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- Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells.PLoS genetics · 2014Article
- Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells.Genes & development · 2014Article
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- Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.Development (Cambridge, England) · 2014Article
- Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner.Chromosoma · 2013Article
- Article
- Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster.Genome research · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Heterochromatin is characteristically the last portion of the genome to be replicated. In polytene cells, heterochromatic sequences are underreplicated because S phase ends before replication of heterochromatin is completed. Truncated heterochromatic DNAs have been identified in polytene cells of Drosophila and may be the discontinuous molecules that form between fully replicated euchromatic and underreplicated heterochromatic regions of the chromosome. In this report, we characterize the temporal pattern of heterochromatic DNA truncation during development of polytene cells. Underreplication occurred during the first polytene S phase, yet DNA truncation, which was found within heterochromatic sequences of all four Drosophila chromosomes, did not occur until the second polytene S phase. DNA truncation was correlated with underreplication, since increasing the replication of satellite sequences with the cycE(1672) mutation caused decreased production of truncated DNAs. Finally, truncation of heterochromatic DNAs was neither quantitatively nor qualitatively affected by modifiers of position effect variegation including the Y chromosome, Su(var)205(2), parental origin, or temperature. We propose that heterochromatic satellite sequences present a barrier to DNA replication and that replication forks that transiently stall at such barriers in late S phase of diploid cells are left unresolved in the shortened S phase of polytene cells. DNA truncation then occurs in the second polytene S phase, when new replication forks extend to the position of forks left unresolved in the first polytene S phase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.