ArticleMolecular and cellular biology2000
Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.Nature communications · 2023Article
- Gene mutations in acute promyelocytic leukemia early death in patients treated with arsenic trioxide alone.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Article
- Inherited GATA2 Deficiency Is Dominant by Haploinsufficiency and Displays Incomplete Clinical Penetrance.Journal of clinical immunology · 2021Article
- PML-RARα interferes with erythropoiesis by repressing LMO2 in acute promyelocytic leukaemia.Journal of cellular and molecular medicine · 2018Article
- The B-Box Domain Protein BBX21 Promotes Photomorphogenesis.Plant physiology · 2018Article
- The function, regulation and therapeutic implications of the tumor suppressor protein, PML.Cell & bioscience · 2015Review
- Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia.Oncogene · 2014Article
- HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse.EMBO molecular medicine · 2014Article
- Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.Nature genetics · 2011Article
- Genome-wide functions of PML-RARα in acute promyelocytic leukaemia.British journal of cancer · 2011Review
- GATA Transcription Factors and Cancer.Genes & cancer · 2010Article
- Article
- Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies.Molecular biology of the cell · 2008Article
- Sugar beet contains a large CONSTANS-LIKE gene family including a CO homologue that is independent of the early-bolting (B) gene locus.Journal of experimental botany · 2008Article
- Arabidopsis CONSTANS-LIKE3 is a positive regulator of red light signaling and root growth.The Plant cell · 2006Article
- Cross talk between retinoic acid signaling and transcription factor GATA-2.Molecular and cellular biology · 2004Article
- Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hematopoietically expressed GATA family of transcription factors function as key regulators of blood cell fate. Among these, GATA-2 is implicated in the survival and growth of multipotential progenitors. Here we report that the promyelocytic leukemia protein (PML) can complex with GATA-2 and potentiate its transactivation capacity. The binding is mediated through interaction of the zinc finger region of GATA-2 and the B-box domain of PML. The B-box region of PML is retained in the PML-RARalpha (retinoic acid receptor alpha) fusion protein generated by the t(15;17) translocation characteristic of acute promyelocytic leukemia (APL). Consistent with this, we provide evidence that GATA-2 can physically associate with PML-RARalpha. Functional experiments further demonstrated that this interaction has the capacity to render GATA-dependent transcription inducible by retinoic acid, raising the possibility that GATA target genes may be involved in the molecular pathogenesis of APL.
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