ArticleAmerican journal of human genetics2000
Human mtDNA haplogroups associated with high or reduced spermatozoa motility.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00341120 (Methylenetetrahydrofolate Reductase C677T Mutation, Other Variant Genotypes, and Male Infertility), which is not on this map. Cited by 146 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Methylenetetrahydrofolate Reductase C677T Mutation, Other Variant Genotypes, and Male Infertility
Who cites it
146 citing papers in PubMed, 4 syntheses or guidelines pooled it, 496 citations in OpenAlex.
- Pooled it
- A replication study and meta-analysis of mitochondrial DNA variants in the radiographic progression of knee osteoarthritis.Rheumatology (Oxford, England) · 2017Pooled it
- Pooled it
- Association of polymorphisms of A260G and A386G in DAZL gene with male infertility: a meta-analysis and systemic review.Asian journal of andrologyPooled it
- Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery.Scientific reports · 2019Trial
- Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy.AIDS (London, England) · 2014Trial
- The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy.The pharmacogenomics journal · 2008Trial
- Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats.Aging cell · 2026Article
- Mitochondrial Dysfunction in Autism and Attention-Deficit/Hyperactivity Disorder: Evidence from Genetic, Biochemical, and Neuroimaging Approaches.Antioxidants (Basel, Switzerland) · 2026Review
- High-Resolution Imaging Reveals Mitochondrial Protein Imbalance in Sperm of Oligoasthenospermic Men.Molecular reproduction and development · 2026Article
- The need to understand the underlying mechanisms associated with mitochondrial therapies in assisted reproduction before further clinical trials are performed.Human reproduction (Oxford, England) · 2026Review
- The nuclear and mitochondrial genomes need to tango. How is their dance synchronized during development?NAR molecular medicine · 2026Article
- Testing the Mother's Curse Hypothesis in Human Mitochondrial Genome Evolution.Genome biology and evolution · 2025Article
- Lifestyle and Environmental Factors Affecting Male Fertility, Individual Predisposition, Prevention, and Intervention.International journal of molecular sciences · 2025Review
- The interplay between mitochondrial DNA genotypes, female infertility, ovarian response, and mutagenesis in oocytes.Human reproduction open · 2025Article
- Support for Y-compensation of mother's curse affecting lifespan in Drosophila melanogaster.Heredity · 2024Article
- Abnormal Expression of COX5B Gene and Disorder of Mitochondrial Function in Cryptorchid Rats.Journal of cellular and molecular medicine · 2024Article
- Review
- Mother's Curse effects on lifespan and aging.Frontiers in aging · 2024Review
- Review
86 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of mtDNA mutations responsible for human diseases have been associated with molecular defects in the OXPHOS system. It has been proposed that mtDNA genetic alterations can also be responsible for sperm dysfunction. In addition, it was suggested that if sperm dysfunction is the main phenotypic consequence, these mutations could be fixed as stable mtDNA variants, because mtDNA is maternally inherited. To test this possibility, we have performed an extensive analysis of the distribution of mtDNA haplogroups in white men having fertility problems. We have found that asthenozoospermia, but not oligozoospermia, is associated with mtDNA haplogroups in whites. Thus, haplogroups H and T are significantly more abundant in nonasthenozoospermic and asthenozoospermic populations, respectively, and show significant differences in their OXPHOS performance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.