ArticleNeoplasia (New York, N.Y.)
Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 103 citations in OpenAlex.
- Telomeric Ends and Telomerase-Canonical and Non-Canonical Roles in Breast Cancer Tumorigenesis and Therapy Resistance.Biomedicines · 2026Review
- A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic Approaches.Cancers · 2025Review
- Methylation of the telomerase gene promoter region in umbilical cord blood of patients with gestational diabetes mellitus is associated with decreased telomerase expression levels and shortened telomere length.Frontiers in endocrinology · 2025Article
- Telomere Maintenance Mechanisms in Cancer.Genes · 2018Review
- Telomeres and Telomerase in Hematopoietic Dysfunction: Prognostic Implications and Pharmacological Interventions.International journal of molecular sciences · 2017Review
- Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms.Frontiers in genetics · 2016Review
- Insertion of Retrotransposons at Chromosome Ends: Adaptive Response to Chromosome Maintenance.Frontiers in genetics · 2015Review
- An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes.Virology · 2013Article
- Construction of a tumor-specific bioluminescent eukaryotic expression vector and analysis of its expressionOncology letters · 2013Article
- Telomere structure and telomerase in health and disease (review).International journal of oncology · 2012Review
- Review
- Telomerase regulation.Mutation research · 2012Review
- Use of the comet-FISH assay to compare DNA damage and repair in p53 and hTERT genes following ionizing radiation.PloS one · 2012Article
- Chromosome arm-specific long telomeres: a new clonal event in primary chronic myelogenous leukemia cells.Neoplasia (New York, N.Y.) · 2011Article
- Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck.Carcinogenesis · 2010Article
- A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells.Cancer science · 2008Review
- Article
- Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.Oncogene · 2003Article
- Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome.American journal of human genetics · 2003Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Telomerase, the enzyme that maintains the ends of chromosomes, is absent from the majority of somatic cells but is present and active in most tumours. The gene for the reverse transcriptase component of telomerase (hTERT) has recently been identified. A cDNA clone of this gene was used as a probe to identify three genomic bacterial artificial chromosome (BAC) clones, one of which was used as a probe to map hTERT by fluorescence in situ hybridization (FISH) to chromosome 5p15.33. This BAC probe was further used to look at copy number of the hTERT region in immortal cell lines. We found that 10/15 immortal cell lines had a modal copy number of 3 or more per cell, with one cell line (CaSki) having a modal copy number of 11. This suggests that increases in copy number of the hTERT gene region do occur, and may well be one route to upregulating telomerase levels in tumour cells. 5p15 gains and amplifications have been documented for various tumour types, including non-small cell lung carcinoma, squamous cell carcinoma of head and neck, and uterine cervix cancer, making hTERT a potential target.
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