ArticleNeoplasia (New York, N.Y.)1999
Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma.
Article in Neoplasia (New York, N.Y.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 89 citations in OpenAlex.
- Gene Amplification in Rhabdomyosarcoma: Lessons from a Rare Cancer.International journal of molecular sciences · 2026Review
- Sequential genomic analysis using a multisample/multiplatform approach to better define rhabdomyosarcoma progression and relapse.NPJ precision oncology · 2023Article
- Review
- Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma.International journal of molecular sciences · 2018Article
- Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma via c-myc-dependent and -independent events.Scientific reports · 2017Article
- Classification of rhabdomyosarcoma and its molecular basis.Advances in anatomic pathology · 2013Review
- Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.PLoS genetics · 2013Article
- Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array.Cancer science · 2013Article
- Genomic and clinical analysis of fusion gene amplification in rhabdomyosarcoma: a report from the Children's Oncology Group.Genes, chromosomes & cancer · 2012Article
- Genomic and clinical analysis of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.Genes, chromosomes & cancer · 2009Article
- Constitutional aneuploidy and cancer predisposition.Human molecular genetics · 2009Review
- Advantage of FISH analysis using FKHR probes for an adjunct to diagnosis of rhabdomyosarcomas.Virchows Archiv : an international journal of pathology · 2008Article
- Diagnostic and prognostic sarcoma signatures.Molecular diagnosis & therapy · 2008Review
- An approach to the validation of novel molecular markers of breast cancer via TMA-based FISH scanning.Journal of molecular histology · 2007Article
- Malignant and benign ganglioglioma: a pathological and molecular study.Neuro-oncology · 2007Article
- Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors.Neoplasia (New York, N.Y.) · 2006Article
- Detection of chromosomal regions showing differential gene expression in human skeletal muscle and in alveolar rhabdomyosarcoma.BMC bioinformatics · 2004Article
- Myostatin inhibits rhabdomyosarcoma cell proliferation through an Rb-independent pathway.Oncogene · 2004Article
- Molecular genetics of pediatric soft tissue tumors: clinical application.The Journal of molecular diagnostics : JMD · 2003Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhabdomyosarcoma (RMS) in children occurs predominantly as two major histologically defined subtypes called embryonal RMS (RMS-E) and the prognostically less favorable alveolar RMS (RMS-A). Comparative genomic hybridization (CGH) was performed on 21 RMS and identified consistent gains affecting chromosomes 2 (8/10), 5 (5/10), 6 (3/10), 7 (7/10), 8 (9/10), 11 (6/ 10), and 12 (5/10) in RMS-E. Losses/deletions involved chromosomes 19 (2/10) and chromosomes 4, 9, 10, 17, 21 (1/10 each). High copy number amplification, involving the 2p24 region (5/11) and less frequently, the 12q13-21 (2/11), 9p22 (1/11), and 17q22-25 (1/11) regions, was detected in RMS-A. Gene amplification at band 2p24 was present in 6/12 alveolar tumors, and in each case, MYCN was amplified, together with the distally placed DDX1 gene. For these patients there was a shorter disease free interval and a higher mortality than patients with tumors without amplification. Detailed spectral karyotype analysis (SKY) was performed on two RMS cell lines (one of each subtype) and identified a surprisingly high level of structural change. Gene expression studies with the Atlas Human Cancer Array (588 genes) showed that 153 genes generated a signal of similar intensity in both cell lines, and 45 genes appeared to have subtype-specific expression. The chromosomal location of differentially expressed genes was compared to the pattern of genomic alteration in RMS as determined by CGH in this study and the literature.
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