ArticleNeoplasia (New York, N.Y.)1999
Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression.
Article in Neoplasia (New York, N.Y.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia.BMC genomics · 2007Pooled it
- The biogenesis and roles of extrachromosomal oncogene involved in carcinogenesis and evolution.American journal of cancer research · 2020Review
- Review
- Distinct nuclear orientation patterns for mouse chromosome 11 in normal B lymphocytes.BMC cell biology · 2014Article
- c-MYC-induced genomic instability.Cold Spring Harbor perspectives in medicine · 2014Review
- p53 mutations associated with aging-related rise in cancer incidence rates.Cell cycle (Georgetown, Tex.) · 2013Article
- Article
- Myc-dependent genome instability and lifespan in Drosophila.PloS one · 2013Article
- Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Transcription-independent functions of MYC: regulation of translation and DNA replication.Nature reviews. Molecular cell biology · 2008Review
- c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells.Neoplasia (New York, N.Y.) · 2007Article
- Article
- c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Elongated mouse chromosomes suitable for enhanced molecular cytogenetics.Cytotechnology · 2004Article
- Rearrangements of the telomeric region of mouse chromosome 11 in Pre-B ABL/MYC cells revealed by mBANDing, spectral karyotyping, and fluorescence in-situ hybridization with a subtelomeric probe.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Article
- c-MYC overexpression in Ba/F3 cells simultaneously elicits genomic instability and apoptosis.Oncogene · 2002Article
- Article
- Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability.Genetics · 2002Article
- c-Myc-induced extrachromosomal elements carry active chromatin.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
We examined the expression of cyclins D1, D2, D3, and E in mouse B-lymphocytic tumors. Cyclin D2 mRNA was consistently elevated in plasmacytomas, which characteristically contain Myc-activating chromosome translocations and constitutive c-Myc mRNA and protein expression. We examined the nature of cyclin D2 overexpression in plasmacytomas and other tumors. Human and mouse tumor cell lines that exhibited c-Myc dysregulation displayed instability of the cyclin D2 gene, detected by Southern blot, fluorescent in situ hybridization (FISH), and in extrachromosomal preparations (Hirt extracts). Cyclin D2 instability was not seen in cells with low levels of c-Myc protein. To unequivocally demonstrate a role of c-Myc in the instability of the cyclin D2 gene, a Myc-estrogen receptor chimera was activated in two mouse cell lines. After 3 to 4 days of Myc-ER activation, instability at the cyclin D2 locus was seen in the form of extrachromosomal elements, determined by FISH of metaphase and interphase nuclei and of purified extrachromosomal elements. At the same time points, Northern and Western blot analyses detected increased cyclin D2 mRNA and protein levels. These data suggest that Myc-induced genomic instability may contribute to neoplasia by increasing the levels of a cell cycle-regulating protein, cyclin D2, via intrachromosomal amplification of its gene or generation of extrachromosomal copies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.