ReviewCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2000
Choosing a first-line drug in the management of elevated blood pressure: what is the evidence? 2: Beta-blockers.
Review in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Beta-blockers for hypertension.The Cochrane database of systematic reviews · 2017Pooled it
- Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension.The Cochrane database of systematic reviews · 2016Pooled it
- Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension.The Cochrane database of systematic reviews · 2015Pooled it
- Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension.The Cochrane database of systematic reviews · 2014Pooled it
- Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension.The Cochrane database of systematic reviews · 2014Pooled it
- First-line first? Trends in thiazide prescribing for hypertensive seniors.PLoS medicine · 2005Article
- The double-edged sword of COX-2 selective NSAIDs.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2002Review
- Candesartan cilexetil plus hydrochlorothiazide combination: a review of its use in hypertension.Drugs · 2002Review
- The value of industry-sponsored studies of initial antihypertensive therapies.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2001Article
- What are the elements of good treatment for hypertension?BMJ (Clinical research ed.) · 2001Review
- First-line drugs for hypertension.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2001Article
- Observational studies of antihypertensive medication use and compliance: is drug choice a factor in treatment adherence?Current hypertension reports · 2000Review
- Choosing a first-line drug in the management of elevated blood pressure: what is the evidence? 3: Angiotensin-converting-enzyme inhibitors.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2000Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated blood pressure is associated with an increased risk of cardiovascular illness and death. Efforts to reduce that risk have led to recommendations for a wide array of nondrug and drug therapies. Choosing the optimal first-line drug for hypertensive patients should address a hierarchy of treatment goals: decrease in morbidity and mortality associated with hypertension, decrease in blood pressure, good tolerance, dosing convenience and low cost. This article examines the evidence for beta-blockers as a class of first-line antihypertensive drugs in light of these treatment goals. The evidence indicates that beta-blockers are probably not as effective in reducing morbidity and mortality as low-dose thiazide diuretics and that there may be significant differences in effectiveness among various beta-blockers.
Indexed as
Identifiers
10934984PMC80212What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.