ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
F-actin is concentrated in nonrelease domains at frog neuromuscular junctions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026Review
- Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis.Nature communications · 2023Article
- Review
- Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction.Frontiers in synaptic neuroscience · 2021Article
- A Na,K-ATPase-Fodrin-Actin Membrane Cytoskeleton Complex is Required for Endothelial Fenestra Biogenesis.Cells · 2020Article
- Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion.PloS one · 2012Article
- The role of actin remodeling in the trafficking of intracellular vesicles, transporters, and channels: focusing on aquaporin-2.Pflugers Archiv : European journal of physiology · 2008Review
- Perturbation of syndapin/PACSIN impairs synaptic vesicle recycling evoked by intense stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Synaptic vesicle mobility and presynaptic F-actin are disrupted in a N-ethylmaleimide-sensitive factor allele of Drosophila.Molecular biology of the cell · 2006Article
- Article
- Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals.Proceedings of the National Academy of Sciences of the United States of America · 2004Review
- Effects of wortmannin and latrunculin A on slow endocytosis at the frog neuromuscular junction.The Journal of physiology · 2004Article
- The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis.Molecular biology of the cell · 2003Article
- Bulk membrane retrieval in the synaptic terminal of retinal bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Dynamin at actin tails.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Stages of synapse development defined by dependence on F-actin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To gain insight into the role of F-actin in the organization of synaptic vesicles at release sites, we examined the synaptic distribution of F-actin by using a unique synaptic preparation of frog target-deprived nerve terminals. In this preparation, imaging of the synaptic site was unobstructed by the muscle fiber cytoskeleton, allowing for the examination of hundreds of synaptic sites in their entirety in whole mounts. At target-deprived synaptic sites F-actin was distributed in a ladder-like pattern and was colocalized with beta-fodrin. Surprisingly, F-actin stain, which we localized to the nerve terminal itself, did not overlap a synaptic vesicle marker, suggesting that it was concentrated in nonrelease domains of nerve terminals between clusters of synaptic vesicles. These findings suggest that the majority of the presynaptic F-actin is not involved in tethering synaptic vesicles. Instead, the strategic presynaptic positioning of this cytoskeletal meshwork in nonrelease domains of the nerve terminal suggests alternate functions such as restricting synaptic vesicles to release domains, recycling synaptic vesicles, or stabilizing the nerve terminal.
Indexed as
Identifiers
10934249PMC6772601W1628847938What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.