ArticleThe Journal of experimental medicine2000
Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 176 citations in OpenAlex.
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- Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues.Mucosal immunology · 2025Article
- The gastrointestinal endothelin system: receptors, cellular actions, and involvement in gastrointestinal disorders.Przeglad gastroenterologiczny · 2025Review
- Activation of leukotriene BCellular & molecular immunology · 2024Article
- Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition.PLoS pathogens · 2024Article
- Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia.Leukemia · 2022Article
- Role of leukotriene B4 (LTB4)-LTB4 receptor 1 signaling in post-incisional nociceptive sensitization and local inflammation in mice.PloS one · 2022Article
- Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells.Frontiers in immunology · 2020Review
- BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.Mucosal immunology · 2019Article
- Development of an Optimized LC-MS Method for the Detection of Specialized Pro-Resolving Mediators in Biological Samples.Frontiers in pharmacology · 2019Article
- Stress, inflammation, and eicosanoids: an emerging perspective.Cancer metastasis reviews · 2018Review
- Leukotriene receptors as potential therapeutic targets.The Journal of clinical investigation · 2018Review
- Mast Cell-Dependent CD8Cancer immunology research · 2018Article
- The role of the LTBSeminars in immunology · 2017Review
- The yin and yang of leukotriene BSeminars in immunology · 2017Review
- Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.The Journal of clinical investigation · 2017Article
- Macrophage LTBJournal of lipid research · 2017Article
- Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1.PloS one · 2017Article
- Chemoattractant Receptors BLT1 and CXCR3 Regulate Antitumor Immunity by Facilitating CD8+ T Cell Migration into Tumors.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory Arthritis.Frontiers in immunology · 2016Review
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6 authors at 2 institutions in 1 country.
Funding
Abstract
Leukotrienes are derived from arachidonic acid and serve as mediators of inflammation and immediate hypersensitivity. Leukotriene B(4) (LTB(4)) and leukotriene C(4) (LTC(4)) act through G protein-coupled receptors LTB(4) receptor (BLTR) and Cys-LTR, respectively. To investigate the physiological role of BLTR, we produced mice with a targeted disruption of the BLTR gene. Mice deficient for BLTR (BLTR(-/-)) developed normally and had no apparent hematopoietic abnormalities. Peritoneal neutrophils from BLTR(-/-) mice displayed normal responses to the inflammatory mediators C5a and platelet-activating factor (PAF) but did not respond to LTB(4) for calcium mobilization or chemotaxis. Additionally, LTB(4) elicited peritoneal neutrophil influx in control but not in BLTR(-/-) mice. Thus, BLTR is the sole receptor for LTB(4)-induced inflammation in mice. Neutrophil influx in a peritonitis model and acute ear inflammation in response to arachidonic acid was significantly reduced in BLTR(-/-) mice. In mice, intravenous administration of PAF induces immediate lethal anaphylaxis. Surprisingly, female BLTR(-/-) mice displayed selective survival (6 of 9; P = 0.002) relative to male (1 of 11) mice of PAF-induced anaphylaxis. These results demonstrate the role of BLTR in leukotriene-mediated acute inflammation and an unexpected sex-related involvement in PAF-induced anaphylaxis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.