ArticleThe Journal of experimental medicine2000
Association between kinin B(1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 117 citations in OpenAlex.
- Antagonism of Kinin Receptors B1 and B2 Attenuates Folic Acid-Induced Tubulointerstitial Fibrosis in Mice.Basic & clinical pharmacology & toxicology · 2026Article
- Role of Endothelial Kinin B1 Receptor on the Membrane Potential of Transgenic Rat Aorta.Physiological research · 2022Article
- Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1.The Journal of clinical investigation · 2022Article
- Noscapine, an Emerging Medication for Different Diseases: A Mechanistic Review.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Kinin B1 Receptor Is Important in the Pathogenesis of Myeloperoxidase-Specific ANCA GN.Journal of the American Society of Nephrology : JASN · 2020Article
- General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation.International journal of molecular sciences · 2018Review
- Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.Science translational medicine · 2018Article
- Expression, distribution and function of kinin BBritish journal of pharmacology · 2018Article
- Attenuation of pulmonary ACE2 activity impairs inactivation of des-ArgAmerican journal of physiology. Lung cellular and molecular physiology · 2018Article
- Kinin B1 receptor deficiency attenuates cisplatin-induced acute kidney injury by modulating immune cell migration.Journal of molecular medicine (Berlin, Germany) · 2014Article
- Genes, molecules and patients--emerging topics to guide clinical pain research.European journal of pharmacology · 2013Review
- The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi.Frontiers in immunology · 2012Article
- Article
- Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010Article
- Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis.Arteriosclerosis, thrombosis, and vascular biology · 2009Article
- Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice.Journal of neuroinflammation · 2008Article
- Bradykinin [corrected] B1 receptor antagonism is beneficial in renal ischemia-reperfusion injury.PloS one · 2008Article
- Increased susceptibility to endotoxic shock in transgenic rats with endothelial overexpression of kinin B(1) receptors.Journal of molecular medicine (Berlin, Germany) · 2008Article
- A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using intravital microscopy, we examined the role played by B(1) receptors in leukocyte trafficking across mouse mesenteric postcapillary venules in vivo. B(1) receptor blockade attenuated interleukin (IL)-1beta-induced (5 ng intraperitoneally, 2 h) leukocyte-endothelial cell interactions and leukocyte emigration ( approximately 50% reduction). The B(1) receptor agonist des-Arg(9)bradykinin (DABK), although inactive in saline- or IL-8-treated mice, caused marked neutrophil rolling, adhesion, and emigration 24 h after challenge with IL-1beta (when the cellular response to IL-1beta had subsided). Reverse transcriptase polymerase chain reaction and Western blot revealed a temporal association between the DABK-induced response and upregulation of mesenteric B(1) receptor mRNA and de novo protein expression after IL-1beta treatment. DABK-induced leukocyte trafficking was antagonized by the B(1) receptor antagonist des-arg(10)HOE 140 but not by the B(2) receptor antagonist HOE 140. Similarly, DABK effects were maintained in B(2) receptor knockout mice. The DABK-induced responses involved the release of neuropeptides from C fibers, as capsaicin treatment inhibited the responses. Treatment with the neurokinin (NK)(1) and NK(3) receptor antagonists attenuated the responses, whereas NK(2), calcitonin gene-related peptide, or platelet-activating factor receptor antagonists had no effect. Substance P caused leukocyte recruitment that, similar to DABK, was inhibited by NK(1) and NK(3) receptor blockade. Mast cell depletion using compound 48/80 reduced DABK-induced leukocyte trafficking, and DABK treatment was shown histologically to induce mast cell degranulation. DABK-induced trafficking was inhibited by histamine H(1) receptor blockade. Our findings provide clear evidence that B(1) receptors play an important role in the mediation of leukocyte-endothelial cell interactions in postcapillary venules, leading to leukocyte recruitment during an inflammatory response. This involves activation of C fibers and mast cells, release of substance P and histamine, and stimulation of NK(1), NK(3), and H(1) receptors.
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