ArticleThe American journal of pathology2000
Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease.World journal of gastroenterology · 2007Trial
- "Small Hepatocytes" in the Liver.Cells · 2023Review
- Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2020Article
- Viral non-coding RNA inhibits HNF4α expression in HCV associated hepatocellular carcinoma.Infectious agents and cancer · 2015Article
- Ameliorative effect of bone marrow-derived stem cells on injured liver of mice infected with Schistosoma mansoni.The Korean journal of parasitology · 2014Article
- Immunohistochemical characterization of the hepatic progenitor cell compartment in medaka (Oryzias latipes) following hepatic injury.Journal of comparative pathology · 2013Article
- Mutant Hras(G12V) and Kras(G12D) have overlapping, but non-identical effects on hepatocyte growth and transformation frequency in transgenic mice.Liver international : official journal of the International Association for the Study of the Liver · 2012Article
- Effect of mutant β-catenin on liver growth homeostasis and hepatocarcinogenesis in transgenic mice.Liver international : official journal of the International Association for the Study of the Liver · 2011Article
- Management of Liver Failure: From Transplantation to Cell-Based Therapy.Cell medicine · 2011Article
- Article
- Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni.World journal of gastroenterology · 2008Article
- Stem cell therapy for inherited metabolic disorders of the liver.Experimental hematology · 2008Review
- Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells".Histochemistry and cell biology · 2006Article
- Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury.Hepatology (Baltimore, Md.) · 2005Article
- The origin and liver repopulating capacity of murine oval cells.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Hepatic microenvironment affects oval cell localization in albumin-urokinase-type plasminogen activator transgenic mice.The American journal of pathology · 2003Article
- Immunohistochemical study of hepatic oval cells in human chronic viral hepatitis.World journal of gastroenterology · 2001Article
- Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes.The American journal of pathology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Several treatments in rodents, including administration of the alkylating agent dipin, followed by two-thirds partial hepatectomy in mice combine destruction of liver parenchyma with hepatocyte mitoinhibition. These treatments induce proliferation of bile epithelial-like cells (termed oval cells), development of foci composed of small hepatocytes, and eventual replacement of damaged parenchyma by healthy hepatocytes. It has been proposed that these oval cells represent transitional cells in a nonhepatocytic liver facultative stem cell lineage that can give rise to the small hepatocyte foci, and that these foci eventually become confluent and replace liver parenchyma. In this study, we used in vivo cell lineage marking in genetically chimeric livers to test the hypothesis that hepatocytes can serve as the precursor cell type to the small hepatocyte foci that develop in mouse liver after treatment with dipin plus partial hepatectomy. Although we do not exclude the possibility that some small hepatocyte foci may be stem cell-derived, we demonstrate that hepatocyte-derived foci are present after dipin-induced liver damage in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.