ArticleThe American journal of pathology2000
Comparison of the T cell patterns in leprous and cutaneous sarcoid granulomas. Presence of Valpha24-invariant natural killer T cells in T-cell-reactive leprosy together with a highly biased T cell receptor Valpha repertoire.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Specific Biomarkers Involved in Sarcoidosis Diagnosis and Prognosis.International journal of molecular sciences · 2026Article
- Immunopathogenesis of Sarcoidosis.Seminars in respiratory and critical care medicine · 2025Review
- BALF and BLOOD NK- cells in different stages of pulmonary sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2022Article
- Sarcoid-like reaction: a unique response to immunotherapy in malignant melanoma.BMJ case reports · 2021Article
- Emerging Concepts of Adaptive Immunity in Leprosy.Frontiers in immunology · 2018Review
- Myocardial Immunocompetent Cells and Macrophage Phenotypes as Histopathological Surrogates for Diagnosis of Cardiac Sarcoidosis in Japanese.Journal of the American Heart Association · 2016Article
- Natural killer T cells: drivers or passengers in preventing human disease?Nature reviews. Immunology · 2014Article
- Disposal of iNKT cell deficiency and an increase in expression of SLAM signaling factors characterizes sarcoidosis remission: a 4-year longitudinal study.Respiratory research · 2014Article
- MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The sarcoid granuloma: 'epithelioid' or 'lymphocytic-epithelioid' granuloma?Multidisciplinary respiratory medicine · 2012Article
- Analysis of invariant natural killer T cells in human paracoccidioidomycosis.Mycopathologia · 2011Article
- Adaptive immune responses in primary cutaneous sarcoidosis.Clinical & developmental immunology · 2011Review
- Dendritic cells in the pathogenesis of sarcoidosis.American journal of respiratory cell and molecular biology · 2010Review
- Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.Clinical immunology (Orlando, Fla.) · 2008Article
- Role of CD4+ T cells in sarcoidosis.Proceedings of the American Thoracic Society · 2007Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The T-cell-reactive (eg, tuberculoid and reversal) forms of leprosy represent a well-defined granulomatous reaction pattern against an invading pathogen. The immune response in cutaneous sarcoidosis is a granulomatous condition that pathologically is very similar to T-cell reactive leprosy. However, it lacks a defined causative agent. In view of the role of NKT cells in murine granulomas induced by mycobacterial cell walls, we have searched for the presence of NKT cells in the cutaneous lesions of both leprosy and sarcoidosis. These cells were present in T-cell-reactive leprosy but were undetectable in cutaneous sarcoidosis. We have also studied the TCR Valpha repertoire in the two diseases. In addition to Valpha24(+) NKT cells, all patients with T-cell-reactive leprosy showed a very restricted T-cell-reactive Valpha repertoire with a strong bias toward the use of the Valpha6 and Valpha14 segments. Valpha6 and Valpha14(+) T cells were polyclonal in terms of CDR3 length and Jalpha usage. In contrast, most sarcoidosis patients showed a diverse usage of Valpha chains associated with clonal or oligoclonal expansions reminiscent of antigen-driven activation of conventional T cells. Thus the origin and perpetuation of the two kinds of granulomatous lesions appear to depend on altogether distinct T-cell recruiting mechanisms.
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