ArticleThe American journal of pathology2000
Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- CD80 as an Important Immune Mediator and Therapeutic Target in Atherosclerosis.International journal of molecular sciences · 2026Review
- Integrative Omics Analysis Reveals a CD206Barrier immunity · 2026Article
- Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4International journal of drug discovery and pharmacology · 2024Article
- ACTH treatment promotes murine cardiac allograft acceptance.JCI insight · 2021Article
- T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.Nature reviews. Cardiology · 2019Review
- Expression of CD80 and CD86 on B cells during coxsackievirus B3-induced acute myocarditis.Central-European journal of immunology · 2019Article
- The human blood DNA methylome identifies crucial role of β-catenin in the pathogenesis of Kawasaki disease.Oncotarget · 2018Article
- CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis.Inflammation · 2018Article
- Upregulation of Programmed Death-1 and Its Ligand in Cardiac Injury Models: Interaction with GADD153.PloS one · 2015Article
- CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis.Journal of neuroinflammation · 2014Article
- Adaptive immunity and atherosclerosis: mouse tales in the AJP.The American journal of pathology · 2013Review
- Transcriptomic analysis of peritoneal cells in a mouse model of sepsis: confirmatory and novel results in early and late sepsis.BMC genomics · 2012Article
- PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- T cell costimulatory and coinhibitory pathways in vascular inflammatory diseases.Frontiers in physiology · 2012Article
- Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2009Article
- Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Quantitative analysis of myocardial inflammation by flow cytometry in murine autoimmune myocarditis: correlation with cardiac function.The American journal of pathology · 2004Article
- Sepsis-induced changes in macrophage co-stimulatory molecule expression: CD86 as a regulator of anti-inflammatory IL-10 response.Surgical infections · 2004Article
- Cellular mechanisms that cause suppressed gamma interferon secretion in endotoxin-tolerant mice.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To investigate the roles of B7-1 and/or B7-2 co-stimulatory molecule in the development of graft arterial disease (GAD), major histocompatibility complex (MHC) class II-mismatched allograft hearts were transplanted into wild-type, B7-1(-/-), B7-2(-/-), or B7-1/B7-2(-/-) recipient mice. Grafts were explanted at 4 or 8 weeks and used for histological and immunohistochemical analyses, RNase protection assay, and flow cytometry of graft infiltrating cells. Grafts in wild-type recipients showed macrophage, recipient MHC class II, and B7 molecule co-localization by immunohistochemistry to GAD lesions. Flow cytometry revealed that CD11b(+) and MHC class II(+) graft infiltrating cells expressed B7-1 more than B7-2, whereas B7-2 expression was predominant in CD11b(-) cells at 4 and 8 weeks. GAD was significantly attenuated in the allografts in B7-1(-/-) and B7-1/B7-2(-/-) but not in B7-2(-/-) recipients compared to wild-type hosts. Interferon-gamma mRNA levels were comparable in all graft combinations, whereas interleukin-4 mRNA levels decreased in grafts in B7-2 deficient hosts, but did not correlate with GAD attenuation. The findings indicate distinct roles for B7-1 and B7-2 co-stimulatory molecules in the development of GAD, potentially because of differential expression of B7-1 and B7-2 molecules on distinct stimulator and/or effector cell populations.
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