ArticleJournal of virology2000
A monomeric GTPase-negative MxA mutant with antiviral activity.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- Article
- Article
- Mouse guanylate-binding proteins of the chromosome 3 cluster do not mediate antiviral activity in vitro or in mouse models of infection.Communications biology · 2024Article
- The Antiviral Activity of Equine Mx1 against Thogoto Virus Is Determined by the Molecular Structure of Its Viral Specificity Region.Journal of virology · 2023Article
- Article
- Crosstalk Between SUMO and Ubiquitin-Like Proteins: Implication for Antiviral Defense.Frontiers in cell and developmental biology · 2021Review
- Role of Clathrin and Dynamin in Clathrin Mediated Endocytosis/Synaptic Vesicle Recycling and Implications in Neurological Diseases.Frontiers in cellular neuroscience · 2021Review
- Rescue of a Vaccinia Virus Mutant Lacking IFN Resistance Genes K1L and C7L by theFrontiers in microbiology · 2020Article
- Rhabdoviruses, Antiviral Defense, and SUMO Pathway.Viruses · 2018Review
- Regulation of dynamin family proteins by post-translational modifications.Journal of biosciences · 2017Review
- Characterization of Multi-subunit Protein Complexes of Human MxA Using Non-denaturing Polyacrylamide Gel-electrophoresis.Journal of visualized experiments : JoVE · 2016Article
- MxA Mediates SUMO-Induced Resistance to Vesicular Stomatitis Virus.Journal of virology · 2016Article
- A New Role Discovered for IGTP: The Protective Effect of IGTP in ICH-Induced Neuronal Apoptosis.Cellular and molecular neurobiology · 2016Article
- Oligomerization and GTP-binding Requirements of MxA for Viral Target Recognition and Antiviral Activity against Influenza A Virus.The Journal of biological chemistry · 2015Article
- The Curious Case of Type I IFN and MxA: Tipping the Immune Balance in AIDS.Frontiers in immunology · 2014Review
- Mx proteins: antiviral gatekeepers that restrain the uninvited.Microbiology and molecular biology reviews : MMBR · 2013Review
- Article
- Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.The Journal of biological chemistry · 2011Article
- Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus.Journal of virology · 2011Article
- Mx gene diversity and influenza association among five wild dabbling duck species (Anas spp.) in Alaska.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MxA is a large, interferon-induced GTPase with antiviral activity against RNA viruses. It forms large oligomers, but whether oligomerization and GTPase activity are important for antiviral function is not known. The mutant protein MxA(L612K) carries a lysine-for-leucine substitution at position 612 and fails to form oligomers. Here we show that monomeric MxA(L612K) lacks detectable GTPase activity but is capable of inhibiting Thogoto virus in transiently transfected Vero cells or in a Thogoto virus minireplicon system. Likewise, MxA(L612K) inhibited vesicular stomatitis virus multiplication. These findings indicate that MxA monomers are antivirally active and suggest that GTP hydrolysis may not be required for antiviral activity. MxA(L612K) is rapidly degraded in cells, whereas wild-type MxA is stable. We propose that high-molecular-weight MxA oligomers represent a stable intracellular pool from which active MxA monomers are recruited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.