Evidence map›Paper›PMID 10933730›Full record

ArticleJournal of virology2000

The mouse mammary tumor virus transcription enhancers for hematopoietic progenitor and mammary gland cells share functional elements.

F U Reuss, J M Coffin

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Journal of virology · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Replication of enhancer-deficient amphotropic murine leukemia virus in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2001
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

F U ReussForschungsschwerpunkt Angewandte Tumorvirologie F0400, 69120 Heidelberg, Germany. f.reuss@dkfz-heidelberg.de
J M Coffin
German Cancer Research Center · DETufts University · US

Funding

MOLECULAR BIOLOGY OF RETROVIRUSESR35CA044385 · NCI · TUFTS UNIVERSITY BOSTON · PI COFFIN, JOHN M · 1987 to 2000
$916k
NCI NIH HHS R35CA44385
6 · The paper itself

Abstract

Expression of mouse mammary tumor virus (MMTV)-encoded superantigens in B lymphocytes is required for viral transmission and pathogenesis. We have previously established a critical role of an enhancer element within the long terminal repeat (LTR) for MMTV sag gene expression in B-lymphoid progenitor cells. We now demonstrate enhancer activity of this element in a promyelocytic progenitor cell line. We also map the position of the enhancer within the U3 region of the MMTV LTR and show that the progenitor cell enhancer shares functional elements with a previously described mammary gland-specific enhancer.

Indexed as

Enhancer Elements, GeneticTranscription, GeneticAnimalsBase SequenceCell LineEpithelial CellsFemaleGenes, ReporterHematopoietic Stem CellsLuciferasesMammary Glands, AnimalMammary Tumor Virus, MouseMiceMolecular Sequence DataSequence Analysis, DNATerminal Repeat SequencesLuciferases

Identifiers

PMID10933730
PMCPMC112353
OpenAlexW2102548557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.