ArticleJournal of virology2000
Detachment of human immunodeficiency virus type 1 from germinal centers by blocking complement receptor type 2.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Identification and Characterization of chCR2, a Protein That Binds Chicken Complement Component 3d.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- HIV infection and the implication for COVID-19 vaccination.Public health challenges · 2022Review
- HIV-1-Specific Chimeric Antigen Receptor T Cells Fail To Recognize and Eliminate the Follicular Dendritic Cell HIV ReservoirJournal of virology · 2020Article
- Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment.Frontiers in cellular and infection microbiology · 2020Article
- Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity.Frontiers in immunology · 2019Article
- Analysis of Complement-Mediated Lysis of Simian Immunodeficiency Virus (SIV) and SIV-Infected Cells Reveals Sex Differences in Vaccine-Induced Immune Responses in Rhesus Macaques.Journal of virology · 2018Article
- Human Immunodeficiency Virus Playing Hide-and-Seek: Understanding the TFrontiers in immunology · 2017Review
- Complement Evasion Strategies of Viruses: An Overview.Frontiers in microbiology · 2017Review
- Viruses exploit the tissue physiology of the host to spread in vivo.Current opinion in cell biology · 2016Review
- Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.PLoS pathogens · 2015Article
- Article
- Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection.Retrovirology · 2011Article
- Article
- A novel approach to inhibit HIV-1 infection and enhance lysis of HIV by a targeted activator of complement.Virology journal · 2009Article
- Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain.Blood · 2009Article
- B cells in HIV infection and disease.Nature reviews. Immunology · 2009Review
- Review
- Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals.The Journal of experimental medicine · 2008Article
- Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.Journal of virology · 2008Article
- Mechanisms of Host Resistance Against HIV Infection and Progression to AIDS.Sultan Qaboos University medical journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After the transition from the acute to the chronic phase of human immunodeficiency virus (HIV) infection, complement mediates long-term storage of virions in germinal centers (GC) of lymphoid tissue. The contribution of particular complement receptors (CRs) to virus trapping in GC was studied on tonsillar specimens from HIV-infected individuals. CR2 (CD21) was identified as the main binding site for HIV in GC. Monoclonal antibodies (MAb) blocking the CR2-C3d interaction were shown to detach 62 to 77% of HIV type 1 from tonsillar cells of an individual in the presymptomatic stage. Although they did so at a lower efficiency, these antibodies were able to remove HIV from tonsillar cells of patients under highly active antiretroviral therapy, suggesting that the C3d-CR2 interaction remains a primary entrapment mechanism in treated patients as well. In contrast, removal of HIV was not observed with MAb blocking CR1 or CR3. Thus, targeting CR2 may facilitate new approaches toward a reduction of residual virus in GC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.