ArticleProceedings of the National Academy of Sciences of the United States of America2000
Silent synapses in the developing hippocampus: lack of functional AMPA receptors or low probability of glutamate release?
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- Article
- Distinct transmission sites within a synapse for strengthening and homeostasis.Science advances · 2025Article
- Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure.The EMBO journal · 2023Article
- Corticospinal circuit neuroplasticity may involve silent synapses: Implications for functional recovery facilitated by neuromodulation after spinal cord injury.IBRO neuroscience reports · 2023Article
- How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway.International journal of molecular sciences · 2022Review
- BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses.Molecular brain · 2020Article
- Article
- Early Correlated Network Activity in the Hippocampus: Its Putative Role in Shaping Neuronal Circuits.Frontiers in cellular neuroscience · 2017Review
- GABA and glycine in the developing brain.The journal of physiological sciences : JPS · 2016Review
- Lead Exposure Impairs Hippocampus Related Learning and Memory by Altering Synaptic Plasticity and Morphology During Juvenile Period.Molecular neurobiology · 2016Article
- Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior.Pflugers Archiv : European journal of physiology · 2015Article
- Gelidium amansii promotes dendritic spine morphology and synaptogenesis, and modulates NMDA receptor-mediated postsynaptic current.In vitro cellular & developmental biology. Animal · 2014Article
- AMPA-silent synapses in brain development and pathology.Nature reviews. Neuroscience · 2013Review
- Astrocytic vesicle mobility in health and disease.International journal of molecular sciences · 2013Review
- Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes.Molecular brain · 2012Article
- Electrophysiological analysis of circuits controlling energy homeostasis.Molecular neurobiology · 2012Review
- Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus.BMC neuroscience · 2012Article
- Spike-timing dependence of structural plasticity explains cooperative synapse formation in the neocortex.PLoS computational biology · 2012Article
- The dynamic role of beta-catenin in synaptic plasticity.Neuropharmacology · 2012Review
15 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At early developmental stages, silent synapses have been commonly found in different brain areas. These synapses are called silent because they do not respond at rest but are functional at positive membrane potentials. A widely accepted interpretation is that N-methyl-d-aspartate (NMDA) but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are functionally expressed on the subsynaptic membrane. Here we show that, in both CA3 and CA1 hippocampal regions, AMPA-mediated synaptic responses can be detected already at early stages of postnatal development. However, some synapses appear silent because of a very low probability of glutamate release. They can be converted into functional ones by factors that enhance release probability such as paired-pulse stimulation, increasing the temperature or cyclothiazide (CTZ), a drug that blocks AMPA receptor desensitization and increases transmitter release. Conversely, conducting synapses can be switched off by increasing the frequency of stimulation. Although we cannot exclude that "latent AMPA receptors" can become functional after activity-dependent processes, our results clearly indicate that, in the neonatal hippocampus, a proportion of glutamatergic synaptic connections are presynaptically rather than postsynaptically silent.
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