ArticleProceedings of the National Academy of Sciences of the United States of America2000
TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- Shared neoantigens for cancer immunotherapy.Molecular therapy. Oncology · 2025Review
- TARP as antigen in cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2021Review
- Review
- Genetic landscape of external auditory canal squamous cell carcinoma.Cancer science · 2020Observational
- TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment.Haematologica · 2020Article
- Article
- Strategies for developing and optimizing cancer vaccines.F1000Research · 2019Review
- Cancer vaccine strategies: translation from mice to human clinical trials.Cancer immunology, immunotherapy : CII · 2018Review
- Cancer vaccines: translation from mice to human clinical trials.Current opinion in immunology · 2018Review
- Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer.Oncoimmunology · 2016Article
- A Report of the Women's Health Congress Workshop on The Health of Women of Color: A Critical Intersection at the Corner of Sex/Gender and Race/Ethnicity.Journal of women's health (2002) · 2016Article
- Emerging immunotherapeutics in adenocarcinomas: A focus on CAR-T cells.Current trends in immunology · 2016Article
- Reassessing target antigens for adoptive T-cell therapy.Nature biotechnology · 2013Review
- Cancer vaccines: 21st century approaches to harnessing an ancient modality to fight cancer.Expert review of vaccines · 2013Article
- Differentially expressed transcripts and dysregulated signaling pathways and networks in African American breast cancer.PloS one · 2013Article
- Trial watch: Peptide vaccines in cancer therapy.Oncoimmunology · 2012Article
- Molecular characterization of the feline T-cell receptor γ alternate reading frame protein (TARP) ortholog.Journal of veterinary science · 2012Article
- T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Strategies to use immune modulators in therapeutic vaccines against cancer.Seminars in oncology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Previously, we identified the expression of a prostate-specific form of T cell receptor gamma chain (TCRgamma) mRNA in the human prostate and demonstrated that it originates from epithelial cells and not from infiltrating T lymphocytes. Here, we show that this prostate-specific transcript is also expressed in three breast cancer cell lines and breast cancer tissues. Analysis of the cDNA sequence predicts that this transcript can encode two protein products of 7 and 13 kDa, and in vitro translation experiments showed that both proteins were made. The longer ORF encodes a 13-kDa truncated version of TCRgamma, whereas the shorter alternative reading frame encodes a 7-kDa protein with five leucine residues in heptad repeats followed by a basic region. Studies with specific antibodies against each protein product revealed that both prostate and breast cancer cells contain only the 7-kDa protein, which is located in the nucleus. We have named this protein TCRgamma alternate reading frame protein (TARP). These results demonstrate that an alternative protein product is encoded by the TCRgamma locus in cells other than T lymphocytes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.