ArticleProceedings of the National Academy of Sciences of the United States of America2000
Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders.Journal of translational medicine · 2024Article
- Peripheral nerves in the tibial subchondral bone : the role of pain and homeostasis in osteoarthritis.Bone & joint research · 2022Article
- Untangling Peripheral Sympathetic Neurocircuits.Frontiers in cardiovascular medicine · 2022Article
- Nerves in Bone: Evolving Concepts in Pain and Anabolism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Review
- TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons.Cell death & disease · 2018Article
- NT-3 attenuates the growth of human neuron cells through the ERK pathway.Cytotechnology · 2016Article
- Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification.The EMBO journal · 2013Article
- Neurotransmitters in airway parasympathetic neurons altered by neurotrophin-3 and repeated allergen challenge.American journal of respiratory cell and molecular biology · 2010Article
- Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons.Journal of cellular and molecular medicine · 2010Article
- Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents.The Journal of clinical investigation · 2010Article
- Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties.Autonomic neuroscience : basic & clinical · 2009Review
- NT-3 expression in spared DRG and the associated spinal laminae as well as its anterograde transport in sensory neurons following removal of adjacent DRG in cats.Neurochemical research · 2008Article
- Evolutionary conservation of neuropeptide expression in the thymus of different species.Immunology · 2006Article
- Neuron-to-cell spread of pseudorabies virus in a compartmented neuronal culture system.Journal of virology · 2005Article
- Interleukin-6 in neurons of the pterygopalatine ganglion of the rat.Neuroscience and behavioral physiology · 2005Article
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophins influence the epigenetic shaping of the vertebrate nervous system by regulating neuronal numbers during development and synaptic plasticity. Here we attempt to determine whether these growth factors can also regulate neurotransmitter plasticity. As a model system we used the selection between noradrenergic and cholinergic neurotransmission by paravertebral sympathetic neurons. Developing sympathetic neurons express the neurotrophin receptors TrkA and TrkC, two highly related receptor tyrosine kinases. Whereas the TrkA ligand nerve growth factor (NGF) has long been known to regulate both the survival and the expression of noradrenergic traits in sympathetic neurons, the role of TrkC and of its ligand neurotrophin-3 (NT3) has remained unclear. We found that TrkC expression in the avian sympathetic chain overlaps substantially with that of choline acetyltransferase. In sympathetic chain explants, transcripts of the cholinergic marker genes choline acetyltransferase and vasoactive intestinal polypeptide were strongly enriched in the presence of NT3 compared with NGF, whereas the noradrenergic markers tyrosine hydroxylase and norepinephrine transporter were reduced. The transcription factor chicken achaete scute homolog 1 was coexpressed with cholinergic markers. The effects of NT3 are reversed and antagonized by NGF. They are independent of neuronal survival and developmentally regulated. These results suggest a role for NT3 as a differentiation factor for cholinergic neurons and establish a link between neurotrophins and neurotransmitter plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.