ArticleNucleic acids research2000
Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes.Molecular biology of the cell · 2024Article
- Ixr1 Regulates Ribosomal Gene Transcription and Yeast Response to Cisplatin.Scientific reports · 2018Article
- Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling.The EMBO journal · 2015Article
- Ecologically driven competence for exogenous DNA uptake in yeast.Current microbiology · 2015Review
- The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast.Chemistry and physics of lipids · 2014Review
- Saccharomyces cerevisiae essential genes with an Opi- phenotype.G3 (Bethesda, Md.) · 2014Article
- Review
- Derepression of INO1 transcription requires cooperation between the Ino2p-Ino4p heterodimer and Cbf1p and recruitment of the ISW2 chromatin-remodeling complex.Eukaryotic cell · 2010Article
- Regulators of yeast endocytosis identified by systematic quantitative analysis.The Journal of cell biology · 2009Article
- A SWI/SNF- and INO80-dependent nucleosome movement at the INO1 promoter.Biochemical and biophysical research communications · 2007Article
- Genomic analysis of the Opi- phenotype.Genetics · 2006Article
- Analysis of Opi1p repressor mutants.Current genetics · 2006Article
- A network of transcriptionally coordinated functional modules in Saccharomyces cerevisiae.Genome research · 2005Article
- Genomic analysis of PIS1 gene expression.Eukaryotic cell · 2005Article
- Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Ume6p-Sin3p-Rpd3p complex negatively regulates expression of genes containing a Ume6p binding site. However, these regulatory proteins also function independently to regulate gene expression both negatively and positively. The model system for this combinatorial regulation is the yeast phospholipid biosynthetic pathway. Sin3p negatively regulates the INO1, CHO1, CHO2 and OPI3 genes while Ume6p negatively regulates the INO1 gene and positively regulates the other genes. We have suggested that the positive regulation results from indirect effects on expression of the INO2 transcriptional activator gene. Here, we demonstrate that the effect of Ume6p on INO2 gene expression is also indirect. We also show that Rpd3p is a negative regulator of phospholipid biosynthetic gene expression. The ability of Ume6p, Sin3p and Rpd3p to differentially regulate expression of the phospholipid biosynthetic genes affects phospholipid composition. A sin3 mutant strain lacks detectable levels of phosphatidylethanolamine and elevated levels of phosphatidylcholine (PC) and a rpd3 mutant strain has reduced levels of PC. These alterations in membrane composition suggest that there may exist additional differences in regulation of phospholipid biosynthetic gene expression and that membrane compositions may be coordinated with other biological processes regulated by Ume6p, Sin3p and Rpd3p.
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