ArticleNucleic acids research2000
The spherulites(TM): a promising carrier for oligonucleotide delivery.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 48 citations in OpenAlex.
- Characterization of spherulites as a lipidic carrier for low and high molecular weight agents.Pharmaceutical research · 2013Article
- Lipothioureas as Lipids for Gene Transfection: A Review.Pharmaceuticals (Basel, Switzerland) · 2011Review
- Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Modeling leakage kinetics from multilamellar vesicles for membrane permeability determination: application to glucose.Biophysical journal · 2006Article
- Key role of receptor density in colloid/cell specific interaction: a quantitative biomimetic study on giant vesicles.The European physical journal. E, Soft matterArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concentric multilamellar microvesicles, named spherulites(TM), were evaluated as an oligonucleotide carrier. Up to 80% oligonucleotide was encapsulated in these vesicles. The study was carried out on two different spherulite(TM) formulations. The spherulite(TM) size and stability characteristics are presented. Delivery of encapsulated oligonucleotide was performed on a rat hepatocarcinoma and on a lymphoblastoid T cell line, both expressing the luciferase gene. We showed that spherulites(TM) were able to transfect both adherent and suspension cell lines and deliver the oligonucleotide to the nucleus. Moreover, 48-62% luciferase inhibition was obtained in the rat hepatocarcinoma cell line when the antisense oligonucleotide targeted to the luciferase coding region was encapsulated at 500 nM concentration in spherulites(TM) of different compositions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.