ArticleNucleic acids research2000
K562 cells implicate increased chromatin accessibility in Alu transcriptional activation.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Adenovirus small E1A directs activation of Alu transcription at YAP/TEAD- and AP-1-bound enhancers through interactions with the EP400 chromatin remodeler.Nucleic acids research · 2024Article
- RNA transcription and degradation of Alu retrotransposons depends on sequence features and evolutionary history.G3 (Bethesda, Md.) · 2022Article
- DNA Analysis by Restriction Enzyme (DARE) enables concurrent genomic and epigenomic characterization of single cells.Nucleic acids research · 2019Article
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- Article
- Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA.Nucleic acids research · 2014Article
- p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- LINEs, SINEs and other retroelements: do birds of a feather flock together?Frontiers in bioscience (Landmark edition) · 2012Review
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- siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures.Experimental hematology · 2011Article
- Alu-directed transcriptional regulation of some novel miRNAs.BMC genomics · 2009Article
- C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts.Nucleic acids research · 2009Article
- DNA cleavage and Trp53 differentially affect SINE transcription.Genes, chromosomes & cancer · 2007Article
- Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution.BMC genomics · 2007Article
- Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses.Nucleic acids research · 2006Article
- Genome size and chromatin condensation in vertebrates.Chromosoma · 2005Article
- Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana.Nucleic acids research · 2004Article
- Stress induction of Bm1 RNA in silkworm larvae: SINEs, an unusual class of stress genes.Cell stress & chaperones · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Alu repeats in K562 cells are unusually hypomethylated and far more actively transcribed than those in other human cell lines and somatic tissues. Also, the level of Alu RNA in K562 cells is relatively insensitive to cell stresses, namely heat shock, adenovirus infection and treatment with cycloheximide, which increase the abundance of Alu RNA in HeLa and 293 cells. Recent advances in understanding the interactions between DNA methylation, transcriptional activation and chromatin conformation reveal reasons for the constitutively high level of Alu expression in K562 cells. Methylation represses transcription of transiently transfected Alu templates in all cell lines tested but cell stresses do not relieve this repression suggesting that they activate Alu transcription through another pathway. A relatively large fraction of the Alus within K562 chromatin is accessible to restriction enzyme cleavage and cell stresses increase the chromatin accessibility of Alus in HeLa and 293 cells. Cell stress evidently activates Alu transcription by rapidly remodeling chromatin to recruit additional templates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.