ReviewEnvironmental health perspectives2000
Inorganic dust pneumonias: the metal-related parenchymal disorders.
Review in Environmental health perspectives, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 182 citations in OpenAlex.
- TGF-β2 and KL-6 as potential biomarkers for hard metal lung disease.BMC pulmonary medicine · 2026Article
- Occupational and Hobby Exposures Associated With Myositis Phenotypes in a National Myositis Patient Registry.Arthritis care & research · 2025Article
- Alloyed Airways: Chromium, Beryllium, and Titanium in the Lungs of an Aerospace Veteran.Cureus · 2024Article
- Immune response to zinc oxide inhalation in metal fume fever, and the possible role of IL-17f.Scientific reports · 2023Article
- Synthesis of Ni-Doped Tremolite Fibers to Help Clarify the Aetiology of the Cytotoxic Outcome of Asbestos.Nanomaterials (Basel, Switzerland) · 2023Article
- Evidence That Metal Particles in Cannabis Vape Liquids Limit Measurement Reproducibility.ACS omega · 2022Article
- A comprehensive summary of disease variants implicated in metal allergy.Journal of toxicology and environmental health. Part B, Critical reviews · 2022Review
- Chemical Pneumonitis Caused by the Inhalation of Zinc Oxide Fumes in an Arc Welder.International journal of environmental research and public health · 2022Article
- Sarcoidosis in Northern Ontario hard-rock miners: A case series.American journal of industrial medicine · 2022Article
- Article
- Sarcoidosis: An Occupational Disease?Chest · 2021Review
- The Composition of Emissions from Sanding CorianAerosol and air quality research · 2021Article
- Desquamative interstitial pneumonia induced by metal exposure. A case report and literature review.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2020Review
- Metal-Induced Pulmonary Fibrosis.Current environmental health reports · 2018Review
- Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Interstitial lung diseases associated with metal content in silicone breast implants: a case series.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis.Respiratory medicine case reports · 2018Article
- Welder's pulmonary hemosiderosis associated with systemic iron overload following exacerbation of acute adult T-cell leukemia/lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2017Article
- Reduced egfr, elevated urine protein and low level of personal protective equipment compliance among artisanal small scale gold miners at Bibiani-Ghana: a cross-sectional study.BMC public health · 2017Article
- Determination of Metal Levels in Shamma (Smokeless Tobacco) with Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in Najran, Saudi ArabiaAsian Pacific journal of cancer prevention : APJCP · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years the greatest progress in our understanding of pneumoconioses, other than those produced by asbestos, silica, and coal, has been in the arena of metal-induced parenchymal lung disorders. Inhalation of metal dusts and fumes can induce a wide range of lung pathology, including airways disorders, cancer, and parenchymal diseases. The emphasis of this update is on parenchymal diseases caused by metal inhalation, including granulomatous disease, giant cell interstitial pneumonitis, chemical pneumonitis, and interstitial fibrosis, among others. The clinical characteristics, epidemiology, and pathogenesis of disorders arising from exposure to aluminum, beryllium, cadmium, cobalt, copper, iron, mercury, and nickel are presented in detail. Metal fume fever, an inhalation fever syndrome attributed to exposure to a number of metals, is also discussed. Advances in our knowledge of antigen-specific immunologic reactions in the lung are particularly evident in disorders secondary to beryllium and nickel exposure, where immunologic mechanisms have been well characterized. For example, current evidence suggests that beryllium acts as an antigen, or hapten, and is presented by antigen-presenting cells to CD4+ T cells, which possess specific surface antigen receptors. Other metals such as cadmium and mercury induce nonspecific damage, probably by initiating production of reactive oxygen species. Additionally, genetic susceptibility markers associated with increased risk have been identified in some metal-related diseases such as chronic beryllium disease and hard metal disease. Future research needs include development of biologic markers of metal-induced immunologic disease, detailed characterization of human exposure, examination of gene alleles that might confer risk, and association of exposure data with that of genetic susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.