ReviewEnvironmental health perspectives2000
Silicosis and coal workers' pneumoconiosis.
Review in Environmental health perspectives, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
143 citing papers in PubMed, 4 syntheses or guidelines pooled it, 434 citations in OpenAlex.
- Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Computer-Aided Diagnosis of Coal Workers' Pneumoconiosis in Chest X-ray Radiographs Using Machine Learning: A Systematic Literature Review.International journal of environmental research and public health · 2022Pooled it
- Pulmonary Rehabilitation Can Improve the Functional Capacity and Quality of Life for Pneumoconiosis Patients: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Association between Genetic Variants of Transforming Growth Factor-β1 and Susceptibility of Pneumoconiosis: A Meta-analysis.Chinese medical journal · 2017Pooled it
- E-cigarette aerosol exposure modulates crystalline silica-induced fibrotic responses in the lungs.Archives of toxicology · 2026Article
- Silicosis, Sarcoidosis, and Silicosarcoidosis Are Overlapping Diagnoses and Difficult to Differentiate.American journal of industrial medicine · 2026Article
- Article
- Uncovering the Factors Behind Rising Pneumoconiosis Rates: Central Appalachian Underground Coal Miners as a Case Study.New solutions : a journal of environmental and occupational health policy : NS · 2026Review
- Toxicity of respirable coal dust: An overview of origin, chemistry, mechanisms, and possible remedies.International journal of coal science & technology · 2026Review
- Clinical characteristics and in-hospital outcomes of pneumothorax in pneumoconiosis: a tertiary referral cohort study.Frontiers in medicine · 2026Article
- Long-term survival and the critical role of competing risks in pneumoconiosis: a large-scale retrospective cohort study.Frontiers in public health · 2026Article
- Characterization of engineered stone dust-induced reactive oxygen species generation and cytotoxicityJournal of toxicology and environmental health. Part A · 2026Article
- Extracellular matrix anchored neutrophils drive pulmonary fibrosis in mice.Nature communications · 2025Article
- Silica exposures and silicosis incidence in the Western Australia mining industry.Occupational medicine (Oxford, England) · 2025Article
- Urban Lifestyle and Climate-Driven Environmental Exposures: Immunological Consequences for Pediatric Respiratory Allergies.Immunity, inflammation and disease · 2025Review
- The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury.Scientific reports · 2025Article
- Exploring agglomeration of respirable silica and other particles in coal mine dust.Scientific reports · 2025Article
- Global trends and age-period-cohort effects of chronic respiratory disease mortality attributed to industrial gaseous pollutants from 1990 to 2021.Scientific reports · 2025Article
- Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis.Scientific reports · 2025Article
- Physicochemical Characteristics and Their Variation of Coal Dust Originating from Underground Mining Sites.ACS omega · 2025Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to coal mine dust and/or crystalline silica results in pneumoconiosis with initiation and progression of pulmonary fibrosis. This review presents characteristics of simple and complicated coal workers' pneumoconiosis (CWP) as well as pathologic indices of acute and chronic silicosis by summarizing results of in vitro, animal, and human investigations. These results support four basic mechanisms in the etiology of CWP and silicosis: a) direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring; b) activation of oxidant production by pulmonary phagocytes, which overwhelms the antioxidant defenses and leads to lipid peroxidation, protein nitrosation, cell injury, and lung scarring; c) activation of mediator release from alveolar macrophages and epithelial cells, which leads to recruitment of polymorphonuclear leukocytes and macrophages, resulting in the production of proinflammatory cytokines and reactive species and in further lung injury and scarring; d) secretion of growth factors from alveolar macrophages and epithelial cells, stimulating fibroblast proliferation and eventual scarring. Results of in vitro and animal studies provide a basis for proposing these mechanisms for the initiation and progression of pneumoconiosis. Data obtained from exposed workers lend support to these mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.