ArticleClinical and experimental immunology2000
The differential effect of stress on natural killer T (NKT) and NK cell function.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
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- Obesity modulates NK cell activity via LDL and DUSP1 signaling for populations with adverse social determinants.JCI insight · 2024Article
- A role for B cells in facilitating defense against an NK cell-sensitive lung metastatic tumor is revealed by stress.Journal of neuroimmunology · 2017Article
- Anti-stress effect of theBioscience of microbiota, food and health · 2017Article
- Stress-related programming of autonomic imbalance: role in allergy and asthma.Chemical immunology and allergy · 2012Article
- Epidemiology of stress and asthma: from constricting communities and fragile families to epigenetics.Immunology and allergy clinics of North America · 2011Review
- Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort.American journal of respiratory and critical care medicine · 2010Article
- Perinatal stress and early life programming of lung structure and function.Biological psychology · 2010Review
- Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases.Journal of leukocyte biology · 2009Review
- CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL.The American journal of pathology · 2007Article
- Tumor immune escape mechanisms: impact of the neuroendocrine system.Cancer immunology, immunotherapy : CII · 2006Review
- Alterations of natural killer cell and T-lymphocyte counts in adults infected with human immunodeficiency virus through blood and plasma sold in the past in China and in whom infection has progressed slowly over a long period.Clinical and diagnostic laboratory immunology · 2005Article
- Immunologic states of autoimmune diseases.Immunologic research · 2005Review
- Age-related bias in function of natural killer T cells and granulocytes after stress: reciprocal association of steroid hormones and sympathetic nerves.Clinical and experimental immunology · 2004Article
- Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences.Immunology · 2003Review
- Psychosocial stress augments tumor development through beta-adrenergic activation in mice.Japanese journal of cancer research : Gann · 2002Article
- Resistance and Susceptibility to Malarial Infection: A Host Defense Strategy against Malaria.Iranian journal of parasitologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When C57Bl/6 mice were exposed to restraint stress for 12 h or 24 h, lymphocytopenia was induced in the liver, spleen, and thymus. We examined which types of lymphocytes were sensitive or resistant to such stress by a immunofluorescence test. T cells of thymic origin were sensitive while NKT and NK cells were resistant. In contrast to the increase in the proportion of NK cells, NK activity of liver lymphocytes against YAC-1 targets decreased at 24 h after stress. On the other hand, their NKT cytotoxicity against syngeneic thymocytes increased in parallel with an increase in their proportion. In perforin -/- B6 mice and B6-gld/gld (Fas ligand-) mice, NK cells were found to mediate cytotoxicity through perforin while NKT cells mediated self-reactive cytotoxicity through Fas ligand. These results suggest that stress increases the proportion of both NK and NKT cells, but that NK cytotoxicity is suppressed while self-reactive NKT cytotoxicity is not, due to a diversity of their functional mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.