ArticleClinical and experimental immunology2000
The C5a receptor is expressed by human renal proximal tubular epithelial cells.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Identification of a genetic region linked to tolerance to MRSA infection using Collaborative Cross mice.PLoS genetics · 2024Article
- A Transcriptome Array-Based Approach to Link SGLT-2 and Intrarenal Complement C5 Synthesis in Diabetic Nephropathy.International journal of molecular sciences · 2023Article
- Article
- The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of UropathogenicFrontiers in cellular and infection microbiology · 2022Article
- Immunohistochemical identification of complement peptide C5a receptor 1 (C5aR1) in non-neoplastic and neoplastic human tissues.PloS one · 2021Article
- Article
- The multifaceted role of complement in kidney transplantation.Nature reviews. Nephrology · 2018Review
- Epithelial C5aR1 Signaling Enhances UropathogenicFrontiers in immunology · 2018Article
- Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective.Clinical and experimental immunology · 2016Review
- Does this case hold the answer to one of the worse types of pain in medicine--that of loin pain haematuria syndrome (LPHS).BMJ case reports · 2015Article
- Complement activation in progressive renal disease.World journal of nephrology · 2015Review
- The role of the complement system in acute kidney injury.Seminars in nephrology · 2013Review
- C3a and C5a promote renal ischemia-reperfusion injury.Journal of the American Society of Nephrology : JASN · 2012Article
- C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.Arthritis research & therapy · 2012Article
- New insights for C5a and C5a receptors in sepsis.Frontiers in immunology · 2012Article
- Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Pharmacological targeting of C5a receptors during organ preservation improves kidney graft survival.Clinical and experimental immunology · 2008Article
- New insights into cellular mechanisms during sepsis.Immunologic research · 2006Review
- The role of complement in danger sensing and transmission.Immunologic research · 2006Review
- Increased concentration of the complement split product C5a in acute pyelonephritis during pregnancy.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2005Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
The C5a receptor is expressed by a variety of cell types. These studies demonstrate by immunohistochemistry that the receptor is present on the surface of proximal and distal tubular epithelial cells from normal kidney. In addition, the receptor was detected on transitional epithelial cells of the ureter and bladder. Primary proximal tubular cultures and a proximal tubular cell line both also expressed the C5a receptor, as demonstrated by immunofluorescence and by FACS analysis. The presence of mRNA encoding the receptor was confirmed by reverse transcriptase-polymerase chain reaction analysis. As opposed to its effect on glomerular mesangial cells, the receptor did not mediate a proliferative response by the proximal tubular cells. C5a also did not enhance the synthesis/secretion of transforming growth factor-beta 1, monocyte chemoattractant protein-1, platelet-derived growth factor-AB or tumour necrosis factor-alpha by cultured proximal tubular cells. Therefore, although the C5a receptor clearly is expressed by proximal tubular cells, clarification of its functional relevance on this cell type awaits further studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.