ArticleMolecular biology of the cell2000
Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Identification of dysregulated pathways underlying HTLV-1-associated myelopathy/tropical spastic paraparesis through co-expression network analysis.Journal of neurovirology · 2021Article
- The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes duringOpen biology · 2021Article
- UbcH10 a Major Actor in Cancerogenesis and a Potential Tool for Diagnosis and Therapy.International journal of molecular sciences · 2020Review
- Article
- UBE2C overexpression in melanoma and its essential role in G2/M transition.Journal of Cancer · 2019Article
- High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.Oncology letters · 2016Article
- Atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation.The Journal of biological chemistry · 2015Article
- Using in vivo biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells.Molecular & cellular proteomics : MCP · 2014Article
- Control the host cell cycle: viral regulation of the anaphase-promoting complex.Journal of virology · 2013Review
- Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.The Journal of biological chemistry · 2013Article
- Identification of early induced genes upon water deficit in potato cell cultures by cDNA-AFLP.Journal of plant research · 2013Article
- A monoclonal antibody against a potential cancer biomarker, human ubiquitin-conjugating enzyme E2.Hybridoma (2005) · 2012Article
- The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes.Nucleic acids research · 2012Article
- Time-lapse imaging of neuroblastoma cells to determine cell fate upon gene knockdown.PloS one · 2012Article
- K11-linked ubiquitin chains as novel regulators of cell division.Trends in cell biology · 2011Review
- The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation.Nature reviews. Molecular cell biology · 2011Review
- Processive ubiquitin chain formation by the anaphase-promoting complex.Seminars in cell & developmental biology · 2011Review
- Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.The Journal of cell biology · 2010Article
- Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma.Neoplasia (New York, N.Y.) · 2006Article
- Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progression through mitosis requires the precisely timed ubiquitin-dependent degradation of specific substrates. E2-C is a ubiquitin-conjugating enzyme that plays a critical role with anaphase-promoting complex/cyclosome (APC/C) in progression of and exit from M phase. Here we report that mammalian E2-C is expressed in late G(2)/M phase and is degraded as cells exit from M phase. The mammalian E2-C shows an autoubiquitinating activity leading to covalent conjugation to itself with several ubiquitins. The ubiquitination of E2-C is strongly enhanced by APC/C, resulting in the formation of a polyubiquitin chain. The polyubiquitination of mammalian E2-C occurs only when cells exit from M phase. Furthermore, mammalian E2-C contains two putative destruction boxes that are believed to act as recognition motifs for APC/C. The mutation of this motif reduced the polyubiquitination of mammalian E2-C, resulting in its stabilization. These results suggest that mammalian E2-C is itself a substrate of the APC/C-dependent proteolysis machinery, and that the periodic expression of mammalian E2-C may be a novel autoregulatory system for the control of the APC/C activity and its substrate specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.