ArticleMolecular biology of the cell2000
Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 80 citations in OpenAlex.
- Article
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- The Neuroproteomic Basis of Enhanced Perception and Processing of Brood Signals That Trigger Increased Reproductive Investment in Honeybee (Molecular & cellular proteomics : MCP · 2020Article
- Interfering with Autophagy: The Opposing Strategies Deployed byFrontiers in cellular and infection microbiology · 2020Review
- A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes.Molecular biology of the cell · 2019Article
- Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation.Developmental cell · 2019Article
- Plasma membrane cholesterol trafficking in steroidogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport.The EMBO journal · 2018Article
- MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.EMBO reports · 2018Article
- Article
- Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3.Journal of lipid research · 2018Article
- Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.The Journal of cell biology · 2018Article
- Phylogenetic Analysis of the vesicular fusion SNARE machinery revealing its functional divergence across Eukaryotes.Bioinformation · 2018Article
- Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.Nature communications · 2017Article
- SNARE-Mediated Cholesterol Movement to Mitochondria Supports Steroidogenesis in Rodent Cells.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Expression and subcellular localization of the Qa-SNARE syntaxin17 in human eosinophils.Experimental cell research · 2015Article
- Mechanisms for exporting large-sized cargoes from the endoplasmic reticulum.Cellular and molecular life sciences : CMLS · 2015Review
- Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.The Journal of biological chemistry · 2015Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endoplasmic reticulum (ER) consists of subcompartments that have distinct protein constituents, morphological appearances, and functions. To understand the mechanisms that regulate the intricate and dynamic organization of the endoplasmic reticulum, it is important to identify and characterize the molecular machinery involved in the assembly and maintenance of the different subcompartments. Here we report that syntaxin 17 is abundantly expressed in steroidogenic cell types and specifically localizes to smooth membranes of the ER. By immunoprecipitation analyses, syntaxin 17 exists in complexes with a syntaxin regulatory protein, rsly1, and/or two intermediate compartment SNARE proteins, rsec22b and rbet1. Furthermore, we found that syntaxin 17 is anchored to the smooth endoplasmic reticulum through an unusual mechanism, requiring two adjacent hydrophobic domains near its carboxyl terminus. Converging lines of evidence indicate that syntaxin 17 functions in a vesicle-trafficking step to the smooth-surfaced tubular ER membranes that are abundant in steroidogenic cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.