ArticleMolecular biology of the cell2000
The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 31 citations in OpenAlex.
- Inducing radiation resilience in frozen animal cells via mRNA coding for tardigrade damage-suppressor protein in support of space travel and Lunar storage.The Journal of heredity · 2026Article
- Synthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecin.Genetics · 2014Article
- Protective effects of Korean red ginseng against radiation-induced apoptosis in human HaCaT keratinocytes.Journal of radiation research · 2014Article
- Contribution of yeast models to neurodegeneration research.Journal of biomedicine & biotechnology · 2012Review
- Non-conservative homologous recombination in human B lymphocytes is promoted by activation-induced cytidine deaminase and transcription.Nucleic acids research · 2008Article
- Tissue-specific differences in the accumulation of sequence rearrangements with age.DNA repair · 2008Article
- Ionizing irradiation effects on S-phase in checkpoint mutants of the yeast Saccharomyces cerevisiae.Current genetics · 2003Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Homozygous mutations in the human ATM gene lead to a pleiotropic clinical phenotype of ataxia-telangiectasia (A-T) patients and correlating cellular deficiencies in cells derived from A-T donors. Saccharomyces cerevisiae tel1 mutants lacking Tel1p, which is the closest sequence homologue to the ATM protein, share some of the cellular defects with A-T. Through genetic complementation of A-T cells with the yeast TEL1 gene, we provide evidence that Tel1p can partially compensate for ATM in suppressing hyperrecombination, radiation-induced apoptosis, and telomere shortening. Complementation appears to be independent of p53 activation. The data provided suggest that TEL1 is a functional homologue of human ATM in yeast, and they help to elucidate different cellular and biochemical pathways in human cells regulated by the ATM protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.