ArticleMolecular biology of the cell2000
The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1.Frontiers in immunology · 2024Article
- DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).The Journal of biological chemistry · 2017Article
- Autophagy in UV Damage Response.Photochemistry and photobiology · 2017Review
- Article
- Transcription Blockage Leads to New Beginnings.Biomolecules · 2015Review
- A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression.Nucleic acids research · 2013Article
- The role of mRNA decay in p53-induced gene expression.RNA (New York, N.Y.) · 2011Article
- Article
- Involvement of stromal p53 in tumor-stroma interactions.Seminars in cell & developmental biology · 2010Review
- Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2008Article
- Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis.Oncogene · 2005Article
- Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation.Oncogene · 2005Article
- Regulation of ultraviolet light-induced gene expression by gene size.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage.The EMBO journal · 2003Article
- Article
- UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53.The Biochemical journal · 2002Article
- P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts.Oncogene · 2001Article
- Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation.Oncogene · 2001Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have previously shown that the tumor suppressor p53 can play a protective role against UV-induced apoptosis in human fibroblasts. In the present study, we investigated whether the protective function of p53 expression is established before or after UV irradiation. Using a stable human cell line expressing a murine temperature-sensitive p53 in which p53 function could be tightly and reversibly regulated, we found that functional p53 stimulated the induction of apoptosis when expressed for as little as 4-12 h after UV irradiation and that this induction was not dependent on de novo protein synthesis. In contrast, expression of p53 for 12 h or more before UV irradiation reduced the extent of apoptosis even when functional p53 expression was maintained after irradiation. The protection conferred by p53 required ongoing protein synthesis and correlated with enhanced recovery of mRNA synthesis. Together, these results suggest that p53 induces distinct proapoptotic and antiapoptotic signals and that these opposing activities can be separated both temporally and by their requirement for de novo protein synthesis. These findings may have important implications for the refinement of gene therapy approaches combining p53 with pharmacological agents that target transcription or translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.