ArticleThe Journal of clinical investigation2000
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome.
Article in The Journal of clinical investigation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 108 citations in OpenAlex.
- Predictive value of thyroid function in severe aplastic anemia patients treated with immunosuppressive therapy.Blood science (Baltimore, Md.) · 2024Article
- Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches.Drug design, development and therapy · 2024Review
- Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil).Archives of endocrinology and metabolism · 2023Article
- Prognostic role of euthyroid sick syndrome in MIS-C: results from a single-center observational study.Frontiers in pediatrics · 2023Article
- High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- The cytokine storm and thyroid hormone changes in COVID-19.Journal of endocrinological investigation · 2021Review
- Fulminant Giant Cell Myocarditis vs. Lymphocytic Myocarditis: A Comparison of Their Clinical Characteristics, Treatments, and Outcomes.Frontiers in cardiovascular medicine · 2021Article
- Evaluation of Thyroid Function in Patients Hospitalized for Acute Heart Failure.International journal of endocrinology · 2021Article
- High prevalence of non-thyroidal illness syndrome in patients at long-term care facilities.Endocrine · 2020Article
- Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis.International journal of molecular sciences · 2018Article
- Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report.Journal of endocrinological investigation · 2017Review
- The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-κB activities.Scientific reports · 2017Article
- Thyroid Hormone in the Pediatric Intensive Care Unit.Journal of pediatric intensive care · 2016Review
- Thyroid Hormones, Oxidative Stress, and Inflammation.Mediators of inflammation · 2016Review
- Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms.World journal of methodology · 2015Review
- Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC).The Journal of biological chemistry · 2015Article
- The relationship between deiodinase activity and inflammatory responses under the stimulation of uremic toxins.Journal of translational medicine · 2014Article
- Pain and thyroid hormones.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Review
- Hypothyroidism and mortality among dialysis patients.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- Is there a link between polycystic ovary syndrome and non-thyroidal illness syndrome?Journal of the Turkish German Gynecological Association · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Euthyroid sick syndrome, characterized by low serum 3,5, 3'-triiodothyronine (T(3)) with normal L-thyroxine levels, is associated with a wide variety of disorders including sepsis, malignancy, and AIDS. The degree of low T(3) in circulation has been shown to correlate with the severity of the underlying disorders and with the prognosis. Elevated TNF-alpha levels, which accompany severe illness, are associated with decreased activity of type I 5'-deiodinase (5'-DI) in liver, leading us to speculate that high levels of this factor contribute to euthyroid sick syndrome. Here we demonstrate that the activation of NF-kappa B by TNF-alpha interferes with thyroid-hormone action as demonstrated by impairment of T(3)-dependent induction of 5'-DI gene expression in HepG2 cells. Inhibition of NF-kappa B action by a dominant-negative NF-kappa B reversed this effect and allowed T(3) induction of 5'-DI. Furthermore, we show that an inhibitor of NF-kappa B activation, clarithromycin (CAM), can inhibit TNF-alpha-induced activation of NF-kappa B and restore T(3)-dependent induction of 5'-DI mRNA and enzyme activity. These results suggest that NF-kappa B activation by TNF-alpha is involved in the pathogenesis of euthyroid sick syndrome and that CAM could help prevent a decrease in serum T(3) levels and thus ameliorate euthyroid sick syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.