ArticleCellular and molecular neurobiology2000
Forskolin modulates acetylcholine receptor gating by interacting with the small extracellular loop between the M2 and M3 transmembrane domains.
Article in Cellular and molecular neurobiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
- Isoflurane alters the structure and dynamics of GLIC.Biophysical journal · 2011Article
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2 authors at 1 institution in 1 country.
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Abstract
1. Forskolin acts as an allosteric modulator of muscle-type nicotinic acetylcholine receptors. Receptors from mouse muscle and Torpedo electroplax demonstrate differential sensitivity to inhibition by forskolin. Previous work from this laboratory suggested that the gamma subunit is responsible for this differential sensitivity. 2. We have used a series of mouse/Torpedo species-chimeric gamma subunits to further define the site of forskolin interaction with the gamma subunit. Analysis of the patterns of forskolin inhibition of receptors containing mouse/Torpedo chimeric gamma subunits along with the mouse alpha, beta, and delta subunits suggests that forskolin interacts with the small extracellular domain that links the M2 and M3 transmembrane domains (the M2-M3 linker). 3. We suggest that the M2-M3 linker domain plays an important role in the transduction of ligand binding to the conformational changes that result in channel opening.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.