ReviewDrugs2000
A rational approach to drug therapy of type 2 diabetes mellitus.
Review in Drugs, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 139 citations in OpenAlex.
- Pioglitazone is effective therapy for elderly patients with type 2 diabetes mellitus.Drugs & aging · 2004Trial
- Overview of Ethnobotanical-Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential.Pharmaceutics · 2024Review
- Significant effects ofExperimental and therapeutic medicine · 2021Article
- A Review on Antidiabetic Activity ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Investigation of the synergistic effect of glimepiride and rosuvastatin on alloxan-induced diabetic rat.Journal of diabetes and metabolic disorders · 2020Article
- Evidence-Based Management of Diabetes in Older Adults.Drugs & aging · 2018Review
- Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols.Journal of diabetes research · 2017Review
- Lean diabetes in middle-aged adults: A joint analysis of the German DIVE and DPV registries.PloS one · 2017Article
- Effects of phenolic-rich extracts of Clinacanthus nutans on high fat and high cholesterol diet-induced insulin resistance.BMC complementary and alternative medicine · 2016Article
- Antidiabetic potential of two medicinal plants used in Gabonese folk medicine.BMC complementary and alternative medicine · 2016Article
- Article
- Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside induced lipid peroxidation in rats' pancreas by phenolic extracts of avocado pear leaves and fruit.International journal of biomedical science : IJBS · 2014Article
- In vitro and in silico antidiabetic activity of pyran ester derivative isolated from Tragia cannabina.Asian Pacific journal of tropical biomedicine · 2014Article
- Review
- Use of laser-induced breakdown spectroscopy for the detection of glycemic elements in Indian medicinal plants.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics.Drug design, development and therapy · 2013Article
- Modulation of starch digestion for slow glucose release through "toggling" of activities of mucosal α-glucosidases.The Journal of biological chemistry · 2012Article
- In vitro screening of medicinal plants used in Mexico as antidiabetics with glucosidase and lipase inhibitory activities.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus.Evidence-based complementary and alternative medicine : eCAM · 2012 · on this mapArticle
- Special considerations with insulin therapy in older adults with diabetes mellitus.Drugs & aging · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several new pharmacological agents have recently been developed to optimise the management of type 2 (non-insulin-dependent) diabetes mellitus. The aim of this article is to briefly review the various therapeutic agents available for management of patients with type 2 diabetes mellitus and to suggest a potential approach to drug selection. There are three general therapeutic modalities relevant to diabetes care. The first modality is lifestyle adjustments aimed at improving endogenous insulin sensitivity or insulin effect. This can be achieved by increased physical activity and bodyweight reduction with diet and behavioural modification, and the use of pharmacological agents or surgery. This first modality is not discussed in depth in this article. The second modality involves increasing insulin availability by the administration of exogenous insulin, insulin analogues, sulphonylureas and the new insulin secretagogue, repaglinide. The most frequently encountered adverse effect of these agents is hypoglycaemia. Bodyweight gain can also be a concern, especially in patients who are obese. The association between hyperinsulinaemia and premature atherosclerosis is still a debatable question. The third modality consists of agents such as biguanides and thiazolidinediones which enhance insulin sensitivity, or agents that decrease insulin requirements like the alpha-glucosidase inhibitors. Type 2 diabetes mellitus is a heterogeneous disease with multiple underlying pathophysiological processes. Therapy should be individualised based on the degree of hyperglycaemia, hyperinsulinaemia or insulin deficiency. In addition, several factors have to be considered when prescribing a specific therapeutic agent. These factors include efficacy, safety, affordability and ease of administration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.