ArticleImmunology2000
Inflammatory cytokine production by immunological and foreign body multinucleated giant cells.
Article in Immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 111 citations in OpenAlex.
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- Unraveling and Harnessing the Immune Response at the Cell-Biomaterial Interface for Tissue Engineering Purposes.Advanced healthcare materials · 2024Review
- The Implant-Induced Foreign Body Response Is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Release of TGF-βPharmaceutics · 2023Article
- Monocyte Differentiation on Atomic Layer-Deposited (ALD) Hydroxyapatite Coating on Titanium Substrate.Molecules (Basel, Switzerland) · 2023Article
- Multinucleated Giant Cells: Current Insights in Phenotype, Biological Activities, and Mechanism of Formation.Frontiers in cell and developmental biology · 2022Review
- Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies.Acta biomaterialia · 2021Review
- Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction.Biomaterials · 2021Article
- Macrophages: an indispensable piece of ovarian health.Biology of reproduction · 2021Review
- Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials.Frontiers in bioengineering and biotechnology · 2021Review
- Mutation onVirulence · 2020Article
- Biomaterials-Mediated Regulation of Macrophage Cell Fate.Frontiers in bioengineering and biotechnology · 2020Review
- Identification of Active Sarcoidosis Using Chitotriosidase and Angiotensin-Converting Enzyme.Lung · 2019Article
- Full-Term Human Placental Macrophages EliminateFrontiers in microbiology · 2019Article
- Reduced Number of Adipose Lineage and Endothelial Cells in Epididymal fat in Response to Omega-3 PUFA in Mice Fed High-Fat Diet.Marine drugs · 2018Article
- Cardiovascular Risk in Patients with Prehypertension and the Metabolic Syndrome.Current hypertension reports · 2018Review
- Histopathological findings in wild Nutrias (Myocastor coypus) with Capillaria hepatica infection.The Journal of veterinary medical science · 2017Article
- Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections with Obesity.Journal of proteome research · 2017Observational
- Immunopathogenesis of granulomas in chronic autoinflammatory diseases.Clinical & translational immunology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multinucleated giant cells (MGC) are a common feature of granulomas. The mechanism of their formation has been studied extensively, but their function has not been completely characterized. A new method for the in vivo production of MGC was developed involving subcutaneous injection of microscopic nitrocellulose particles with adsorbed mycobacterial antigens into the footpads of sensitized BALB/c mice (immune [I]-MGC), or by nitrocellulose administration to non-sensitized mice (foreign body [FB]-MGC). The development of granulomas with a highly enriched MGC population was observed 2 weeks after the nitrocellulose injection. MGC were larger with a greater number of nuclei in I-MGC than in FB-MGC. From days 7-28 after nitrocellulose administration, the production of interleukin-1alpha (IL-1alpha) and tumour necrosis factor-alpha (TNF-alpha) was demonstrated in both MGC types by in situ reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. After 2 months, the MGC had ceased production of IL-1alpha and TNF-alpha, but the expression of transforming growth factor-beta (TGF-beta) was very high, occurring together with extensive fibrosis. These results suggest that MGC are an active source of inflammatory cytokines, which can contribute to the initiation, maintenance and down-regulation of granulomatous inflammation induced by immunological and inert substances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.