ArticlePediatric research2000
Ontogeny of Na+/H+ antiporter activity in rat proximal convoluted tubules.
Article in Pediatric research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- The Role of Renal Na+/H+ Exchange in the Regulation of Acid-Base and Sodium Homeostasis in Premature Infants.Physiological research · 2026Review
- Sex differences in prenatal programming of hypertension by dexamethasone.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Developmental changes in renal tubular transport-an overview.Pediatric nephrology (Berlin, Germany) · 2015Review
- Renal NHE expression and activity in neonatal NHE3- and NHE8-null mice.American journal of physiology. Renal physiology · 2015Article
- Glucocorticoids Reduce Renal NHE8 Expression.Physiological reports · 2013Article
- Proximal tubule specific knockout of the Na⁺/H⁺ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion.Journal of molecular medicine (Berlin, Germany) · 2013Article
- Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice.American journal of physiology. Renal physiology · 2012Article
- Acid increases NHE8 surface expression and activity in NRK cells.American journal of physiology. Renal physiology · 2012Article
- Effect of metabolic acidosis on neonatal proximal tubule acidification.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Prenatal programming of rat thick ascending limb chloride transport by low-protein diet and dexamethasone.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Luminal Na(+)/H (+) exchange in the proximal tubule.Pflugers Archiv : European journal of physiology · 2009Review
- Effect of renal denervation on prenatal programming of hypertension and renal tubular transporter abundance.American journal of physiology. Renal physiology · 2008Article
- Developmental changes in proximal tubule NaCl transport.Pediatric nephrology (Berlin, Germany) · 2008Review
- Effect of thyroid hormone on the postnatal renal expression of NHE8.American journal of physiology. Renal physiology · 2008Article
- Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells.American journal of physiology. Renal physiology · 2007Article
- Ontogeny of NHE8 in the rat proximal tubule.American journal of physiology. Renal physiology · 2007Article
- Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone.American journal of physiology. Regulatory, integrative and comparative physiology · 2007Article
- Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.American journal of physiology. Renal physiology · 2006Article
- Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis.American journal of physiology. Renal physiology · 2005Article
- Developmental changes in proximal tubule tight junction proteins.Pediatric research · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neonates have a lower serum bicarbonate level than adults, which is caused by a lower renal threshold for bicarbonate. Eighty percent of bicarbonate reabsorption occurs in the proximal tubule, in which proton secretion is predominantly mediated by a luminal Na+/H+ antiporter. Previous studies have demonstrated that there is a maturational increase in apical membrane rabbit proximal convoluted tubule Na+/H+ antiporter activity. However, in rat brush border membrane vesicles, Na+/H+ activity was higher in neonates than that in adult rats. To examine the maturation of Na+/H+ antiporter activity in rat proximal convoluted tubules, we perfused rat proximal convoluted tubules in vitro. Na+/H+ antiporter activity was assayed as the proton secretory rate on luminal sodium removal. Na+/H+ antiporter activity was 121.2 +/- 18.4 pmol/mm x min in neonatal and 451.8 +/- 40.6 pmol/mm x min in adult proximal convoluted tubules (p < 0.001). We next examined whether the increase in Na+/H+ antiporter activity was associated with changes in renal cortical NHE3 mRNA and brush border membrane NHE3 protein abundance. Adult renal cortical NHE3 mRNA abundance was 10-fold greater than that in 1-d-old neonates (p < 0.001). There was a comparable developmental increase in renal brush border membrane vesicle NHE3 protein abundance (p < 0.001). In summary, this study demonstrates that there is a maturational increase in rat apical membrane Na+/H+ antiporter activity, renal cortical NHE3 mRNA, and brush border membrane vesicle NHE3 protein abundance.
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