ArticleGenetics2000
Molecular evolution of the avian CHD1 genes on the Z and W sex chromosomes.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 75 citations in OpenAlex.
- The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch.Ecology and evolution · 2026Article
- The spindlin gene as a universal marker for molecular sex identification in different poultry species.Poultry science · 2026Article
- Cross-Species Validation of Pigeon-Specific CHD1 Primers for Molecular Sexing in Pet Birds.International journal of molecular sciences · 2025Article
- Effects of nest locations on foraging behavior and physiological responses in seabird colony.Frontiers in physiology · 2025Article
- Laser microdissection-based analysis of the Y sex chromosome of the Antarctic fish Chionodracohamatus (Notothenioidei, Channichthyidae).Comparative cytogenetics · 2015Article
- Molecular sex identification of painted storks (Mycteria leucocephala): using FTA cards, horizontal PAGE and quick silver staining.Journal of genetics · 2013Article
- Article
- A W-linked palindrome and gene conversion in New World sparrows and blackbirds.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Characteristics, causes and evolutionary consequences of male-biased mutation.Proceedings. Biological sciences · 2007Review
- Substitution rate heterogeneity and the male mutation bias.Journal of molecular evolution · 2006Article
- Fast accumulation of nonsynonymous mutations on the female-specific W chromosome in birds.Journal of molecular evolution · 2006Article
- Sex chromosome evolution: molecular aspects of Y-chromosome degeneration in Drosophila.Genome research · 2005Article
- A gradual process of recombination restriction in the evolutionary history of the sex chromosomes in dioecious plants.PLoS biology · 2005Article
- Evolutionary strata on the chicken Z chromosome: implications for sex chromosome evolution.Genetics · 2004Article
- Article
- Hens, cocks and avian sex determination. A quest for genes on Z or W?EMBO reports · 2001Review
- Recombination and nucleotide diversity in the sex chromosomal pseudoautosomal region of the emu, Dromaius novaehollandiae.The Journal of heredityArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes shared between the nonrecombining parts of the two types of sex chromosomes offer a potential means to study the molecular evolution of the same gene exposed to different genomic environments. We have analyzed the molecular evolution of the coding sequence of the first pair of genes found to be shared by the avian Z (present in both sexes) and W (female-specific) sex chromosomes, CHD1Z and CHD1W. We show here that these two genes evolve independently but are highly conserved at nucleotide as well as amino acid levels, thus not indicating a female-specific role of the CHD1W gene. From comparisons of sequence data from three avian lineages, the frequency of nonsynonymous substitutions (K(a)) was found to be higher for CHD1W (1.55 per 100 sites) than for CHD1Z (0.81), while the opposite was found for synonymous substitutions (K(s), 13.5 vs. 22.7). We argue that the lower effective population size and the absence of recombination on the W chromosome will generally imply that nonsynonymous substitutions accumulate faster on this chromosome than on the Z chromosome. The same should be true for the Y chromosome relative to the X chromosome in XY systems. Our data are compatible with a male-biased mutation rate, manifested by the faster rate of neutral evolution (synonymous substitutions) on the Z chromosome than on the female-specific W chromosome.
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