ArticleGenetics2000
When did the human population size start increasing?
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed.
- Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.BMC evolutionary biology · 2019Article
- A population genetic interpretation of GWAS findings for human quantitative traits.PLoS biology · 2018Article
- Conservation Genomics of the Declining North American BumblebeeFrontiers in genetics · 2018Article
- The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.Current opinion in genetics & development · 2016Review
- Explosive genetic evidence for explosive human population growth.Current opinion in genetics & development · 2016Review
- Nucleosomes shape DNA polymorphism and divergence.PLoS genetics · 2014Article
- The deleterious mutation load is insensitive to recent population history.Nature genetics · 2014Article
- Evolutionary constraints in the β-globin cluster: the signature of purifying selection at the δ-globin (HBD) locus and its role in developmental gene regulation.Genome biology and evolution · 2013Article
- Article
- Heterogeneity in genetic diversity among non-coding loci fails to fit neutral coalescent models of population history.PloS one · 2012Article
- The many landscapes of recombination in Drosophila melanogaster.PLoS genetics · 2012Article
- Major population expansion of East Asians began before neolithic time: evidence of mtDNA genomes.PloS one · 2011Article
- Forward-time simulation of realistic samples for genome-wide association studies.BMC bioinformatics · 2010Article
- Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup I.Journal of human genetics · 2010Article
- Composite likelihood estimation of demographic parameters.BMC genetics · 2009Article
- Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis.Human genetics · 2009Article
- Article
- Fundamental concepts in genetics: effective population size and patterns of molecular evolution and variation.Nature reviews. Genetics · 2009Review
- The signature of long-standing balancing selection at the human defensin beta-1 promoter.Genome biology · 2008Article
- Detecting clusters of mutations.PloS one · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We analyze the frequency spectra of all available human nuclear sequence data sets by using a model of constant population size followed by exponential growth. Parameters of growth (more extreme than or) comparable to what has been suggested from mtDNA data can be rejected for 6 out of the 10 largest data sets. When the data are separated into African and non-African samples, a constant size no-growth model can be rejected for 4 out of 8 non-African samples. Long-term growth (i.e., starting 50-100 kya) can be rejected for 2 out of 8 African samples and 5 out of 8 non-African ones. Under more complex demographic models, including a bottleneck or population subdivision, more of the data are compatible with long-term growth. One problem with the data used here is that a subset of loci may reflect the action of natural selection as well as of demography. It remains possible that the correct demographic model is one of constant population size followed by long-term growth but that at several loci the demographic signature has been obscured by balancing or diversifying selection. However, it is not clear that the data at these loci are consistent with a simple model of balancing selection; more complicated selective alternatives cannot be tested unless they are made explicit. An alternative explanation is that population size growth is more recent (e.g., upper Paleolithic) and that some of the loci have experienced recent directional selection. Given the available data, the latter hypothesis seems more likely.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.