ArticleAmerican journal of human genetics2000
Segregation analysis of phenotypic components of learning disabilities. I. Nonword memory and digit span.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 76 citations in OpenAlex.
- A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency.Molecular psychiatry · 2005Trial
- Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders.Human genetics · 2016Article
- Genome scan for cognitive trait loci of dyslexia: Rapid naming and rapid switching of letters, numbers, and colors.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Predicting Levels of Reading and Writing Achievement in Typically Developing, English-Speaking 2Learning and individual differences · 2014Article
- Lexical decision as an endophenotype for reading comprehension: an exploration of an association.Development and psychopathology · 2012Article
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- Cognitive skills and literacy performance of Chinese adolescents with and without dyslexia.Reading and writing · 2011Article
- Global processing speed in children with low reading ability and in children and adults with typical reading ability: exploratory factor analytic models.Journal of speech, language, and hearing research : JSLHR · 2011Article
- Genome scan for spelling deficits: effects of verbal IQ on models of transmission and trait gene localization.Behavior genetics · 2011Article
- Etiologies and molecular mechanisms of communication disorders.Journal of developmental and behavioral pediatrics : JDBP · 2010Article
- Inter-relationships among behavioral markers, genes, brain and treatment in dyslexia and dysgraphia.Future neurology · 2010Article
- Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment.Journal of neurodevelopmental disorders · 2009Article
- Developmental learning impairments in a rodent model of nodular heterotopia.Journal of neurodevelopmental disorders · 2009Article
- Same or different? Insights into the etiology of phonological awareness and rapid naming.Biological psychology · 2009Article
- Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple loci.Behavior genetics · 2008Article
- Writing problems in developmental dyslexia: under-recognized and under-treated.Journal of school psychology · 2008Article
- Linkage analyses of chromosomal region 18p11-q12 in dyslexia.Journal of neural transmission (Vienna, Austria : 1996) · 2006Article
- Genomewide scan for real-word reading subphenotypes of dyslexia: novel chromosome 13 locus and genetic complexity.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2006Article
- Genomewide scan identifies susceptibility locus for dyslexia on Xq27 in an extended Dutch family.Journal of medical genetics · 2004Article
- Highly significant linkage to the SLI1 locus in an expanded sample of individuals affected by specific language impairment.American journal of human genetics · 2004Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Dyslexia is a common and complex disorder with evidence for a genetic component. Multiple loci (i.e., quantitative-trait loci [QTLs]) are likely to be involved, but the number is unknown. Diagnosis is complicated by the lack of a standard protocol, and many diagnostic measures have been proposed as understanding of the component processes has evolved. One or more genes may, in turn, influence these measures. To date, little work has been done to evaluate the mode of inheritance of individual component-as opposed to composite-phenotypes, beyond family or twin correlation studies that initially demonstrate evidence for a genetic basis of such components. Here we use two approaches to segregation analysis in 102 nuclear families to estimate genetic models for component phenotypes associated with dyslexia: digit span and a nonword-repetition task. Both measures are related to phonological skills, one of the key component processes in dyslexia. We use oligogenic-trait segregation analysis to estimate the number of QTLs contributing to each phenotype, and we use complex segregation analysis to identify the most parsimonious inheritance models. We provide evidence in support of both a major-gene mode of inheritance for the nonword-repetition task, with approximately 2.4 contributing QTLs, and for a genetic basis of digit span, with approximately 1.9 contributing QTLs. Results obtained by reciprocal adjustment of measures suggest that genes contributing to digit span may contribute to the nonword-repetition score but that there are additional QTLs involved in nonword repetition. Our study adds to existing studies of the genetic basis of composite phenotypes related to dyslexia, by providing evidence for major-gene modes of inheritance of these single-measure component phenotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.