ArticleProceedings of the National Academy of Sciences of the United States of America2000
Gastrulation defective is a serine protease involved in activating the receptor toll to polarize the Drosophila embryo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.Hereditas · 2022Article
- Expression and Function of Toll Pathway Components in the Early Development of the WaspJournal of developmental biology · 2022Article
- Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition.Developmental cell · 2018Article
- Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila.PloS one · 2013Article
- A ventrally localized protease in the Drosophila egg controls embryo dorsoventral polarity.Current biology : CB · 2012Article
- Article
- Structure-function analysis of grass clip serine protease involved in Drosophila Toll pathway activation.The Journal of biological chemistry · 2011Article
- Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.FEBS letters · 2010Article
- A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamics.Genome biology · 2006Article
- Purification and characterization of serine proteases that exhibit caspase-like activity and are associated with programmed cell death in Avena sativa.The Plant cell · 2004Article
- Article
- Gastrulation defective, a complement factor C2/B-like protease, interprets a ventral prepattern in Drosophila.EMBO reports · 2001Article
- Activation of a protease cascade involved in patterning the Drosophila embryo.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- No requirement for localized Nudel protein expression in Drosophila embryonic axis determination.FlyArticle
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The dorsoventral axis of the Drosophila embryo is induced by a ventrally restricted ligand for the receptor Toll. The Toll ligand is generated by a proteolytic processing reaction, which occurs at the end of a proteolytic cascade and requires the gastrulation defective (gd), nudel, pipe, and windbeutel genes. Here we demonstrate that the GD protein is a serine protease and that the three other genes act to restrict GD activity to the ventral side of the embryo. Our data support a model in which the GD protease catalyzes the ventral activation of the proteolytic cascade that produces the Toll ligand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.