ArticleProceedings of the National Academy of Sciences of the United States of America2000
Suramin inhibits initiation of defense signaling by systemin, chitosan, and a beta-glucan elicitor in suspension-cultured Lycopersicon peruvianum cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 67 citations in OpenAlex.
- Structure-Function Analysis of Volatile (Z)-3-Fatty Alcohols in Tomato.Journal of chemical ecology · 2025Article
- Survey of Sensitivity to Fatty Acid-Amino Acid Conjugates in the Solanaceae.Journal of chemical ecology · 2020Article
- Activation of disease resistance againstHorticulture research · 2018Article
- Suppression of cell membrane permeability by suramin: involvement of its inhibitory actions on connexin 43 hemichannels.British journal of pharmacology · 2014Article
- Small signaling peptides in Arabidopsis development: how cells communicate over a short distance.The Plant cell · 2012Review
- UV-B induced transcript accumulation of DAHP synthase in suspension-cultured Catharanthus roseus cells.Journal of molecular signaling · 2010Article
- The tomato brassinosteroid receptor BRI1 increases binding of systemin to tobacco plasma membranes, but is not involved in systemin signaling.Plant molecular biology · 2009Article
- Micro-electrode flux estimation confirms that the Solanum pimpinellifolium cu3 mutant still responds to systemin.Plant physiology · 2008Article
- UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures.BMC plant biology · 2007Article
- Article
- The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- Systemins: a functionally defined family of peptide signals that regulate defensive genes in Solanaceae species.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Article
- Salt stress activation of wound-related genes in tomato plants.Plant physiology · 2003Article
- Hyperphosphorylation of a mitochondrial protein, prohibitin, is induced by calyculin A in a rice lesion-mimic mutant cdr1.Plant physiology · 2003Article
- Convergent responses to stress. Solar ultraviolet-B radiation and Manduca sexta herbivory elicit overlapping transcriptional responses in field-grown plants of Nicotiana longiflora.Plant physiology · 2003Article
- N-acylethanolamine signaling in tobacco is mediated by a membrane-associated, high-affinity binding protein.Plant physiology · 2003Article
- The systemin receptor SR160 from Lycopersicon peruvianum is a member of the LRR receptor kinase family.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemin-mediated defense signaling in tomato (Lycopersicon esculentum) plants is analogous to the cytokine-mediated inflammatory response in animals. Herein, we report that the initiation of defense signaling in suspension-cultured cells of Lycopersicon peruvianum by the peptide systemin, as well as by chitosan and beta-glucan elicitor from Phytophtora megasperma, is inhibited by the polysulfonated naphtylurea compound suramin, a known inhibitor of cytokine and growth factor receptor interactions in animal cells. Using a radioreceptor assay, we show that suramin interfered with the binding of the systemin analog (125)I-Tyr-2, Ala-15-systemin to the systemin receptor with an IC(50) of 160 microM. Additionally, labeling of the systemin receptor with a photoaffinity analog of systemin was inhibited in the presence of suramin. Receptor-mediated tyrosine phosphorylation of a 48-kDa mitogen-activated protein kinase and alkalinization of the medium of suspension-cultured cells in response to systemin and carbohydrate elicitors were also inhibited by suramin. The inhibition of medium alkalinization by suramin was reversible in the presence of high concentrations of systemin and carbohydrate elicitors. Calyculin A and erythrosin B, intracellular inhibitors of phosphatases and plasma membrane proton ATPases, respectively, both induce medium alkalinization, but neither response was inhibited by suramin. The polysulfonated compound heparin did not inhibit systemin-induced medium alkalinization. NF 007, a suramin derivative, induced medium alkalinization, indicating that neither NF 007 nor heparin interact with elicitor receptors like suramin. The data indicate that cell-surface receptors in plants show some common structural features with animal cytokine and growth factor receptors that can interact with suramin to interfere with ligand binding.
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