ArticleThe Journal of physiology2000
Divergence in the behaviour of the dihydropyridine receptor in muscle.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The process leading from electrical membrane excitation of skeletal muscle fibres to contraction is a classic example of a rapid cellular activation mechanism. Its initial step is a massive release of Ca2+ from a storage compartment, the sarcoplasmic reticulum (SR), into the myoplasm. Ca2+ release occurs through ryanodine receptors (RyRs), homotetrameric ion channel proteins of an enormous mass (ca 2 3 million Da). In excitation-contraction (EC) coupling the type 1 isoform of the RyR (RyR1) is remotely controlled by plasma membrane voltage. A system of narrow invaginations of the plasma membrane, the transverse tubules (T-system), carries the muscle action potential to specialized regions, the triads, where the membranes of the T-system and the terminal cisternae of the SR are in close apposition.
Indexed as
Identifiers
10921999W2462116714What OpenQuestion holds
Registered trials
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