ArticleJournal of clinical microbiology2000
Characterization of Bartonella clarridgeiae flagellin (FlaA) and detection of antiflagellin antibodies in patients with lymphadenopathy.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Sneaky tactics: Ingenious immune evasion mechanisms ofVirulence · 2024Review
- Evaluation of the available animal models forOne health (Amsterdam, Netherlands) · 2024Review
- Metagenomics of culture isolates and insect tissue illuminate the evolution ofMicrobial genomics · 2023Article
- Detection of 41-kDa bacterial flagellin protein by the lymphocyte transformation test-memory lymphocyte immunostimulation assay.American journal of clinical and experimental immunology · 2022Article
- Phylogeny and putative virulence gene analysis of Bartonella bovis.The Journal of veterinary medical science · 2018Article
- Carrion's Disease: the Sound of Silence.Clinical microbiology reviews · 2018Review
- Molecular Mechanisms ofFrontiers in cellular and infection microbiology · 2018Review
- Coexistence of Bartonella henselae and B. clarridgeiae in populations of cats and their fleas in Guatemala.Journal of vector ecology : journal of the Society for Vector Ecology · 2015Article
- Relationship between the Presence of Bartonella Species and Bacterial Loads in Cats and Cat Fleas (Ctenocephalides felis) under Natural Conditions.Applied and environmental microbiology · 2015Article
- Bartonella clarridgeiae bacteremia detected in an asymptomatic blood donor.Journal of clinical microbiology · 2015Article
- Intruders below the radar: molecular pathogenesis of Bartonella spp.Clinical microbiology reviews · 2012Review
- Absence of zoonotic Bartonella species in questing ticks: first detection of Bartonella clarridgeiae and Rickettsia felis in cat fleas in the Netherlands.Parasites & vectors · 2011Article
- Mixed infections, cryptic diversity, and vector-borne pathogens: evidence from Polygenis fleas and Bartonella species.Applied and environmental microbiology · 2007Article
- Population genetic analysis of Bartonella bacilliformis isolates from areas of peru where Carrion's disease is endemic and epidemic.Journal of clinical microbiology · 2004Article
- Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis.Journal of clinical microbiology · 2004Article
- Evaluation of indirect fluorescence antibody assay for detection of Bartonella clarridgeiae and Seroprevalence of B. clarridgeiae among patients with suspected cat scratch disease.Journal of clinical microbiology · 2004Article
- Isolation of Bartonella washoensis from a dog with mitral valve endocarditis.Journal of clinical microbiology · 2003Article
- Hemin binding, functional expression, and complementation analysis of Pap 31 from Bartonella henselae.Journal of bacteriology · 2003Article
- Genetic classification and differentiation of Bartonella species based on comparison of partial ftsZ gene sequences.Journal of clinical microbiology · 2002Article
- Genomic variation of Bartonella henselae strains detected in lymph nodes of patients with cat scratch disease.Journal of clinical microbiology · 2002Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cat scratch disease (CSD) is a frequent clinical outcome of Bartonella henselae infection in humans. Recently, two case reports indicated Bartonella clarridgeiae as an additional causative agent of CSD. Both pathogens have been isolated from domestic cats, which are considered to be their natural reservoir. B. clarridgeiae and B. henselae can be distinguished phenotypically by the presence or absence of flagella, respectively. Separation of the protein content of purified flagella of B. clarridgeiae by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblot analysis indicated that the flagellar filament is mainly composed of a polypeptide with a mass of 41 kDa. N-terminal sequencing of 20 amino acids of this protein revealed a perfect match to the N-terminal sequence of flagellin (FlaA) as deduced from the sequence of the flaA gene cloned from B. clarridgeiae. The flagellin of B. clarridgeiae is closely related to flagellins of Bartonella bacilliformis and several Bartonella-related bacteria. Since flagellar proteins are often immunodominant antigens, we investigated whether antibodies specific for the FlaA protein of B. clarridgeiae are found in patients with CSD or lymphadenopathy. Immunoblotting with 724 sera of patients suffering from lymphadenopathy and 100 healthy controls indicated specific FlaA antibodies in 3.9% of the patients' sera but in none of the controls. B. clarridgeiae FlaA is thus antigenic and expressed in vivo, providing a valuable tool for serological testing. Our results further indicate that B. clarridgeiae might be a possible etiologic agent of CSD or lymphadenopathy. However, it remains to be clarified whether antibodies to the FlaA protein of B. clarridgeiae are a useful indicator of acute infection.
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