ArticleJournal of clinical microbiology2000
Mapping of IS6110 insertion sites in two epidemic strains of Mycobacterium tuberculosis.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.Frontiers in public health · 2025Article
- The MtZ Strain: Molecular Characteristics and Outbreak Investigation of the Most SuccessfulFrontiers in cellular and infection microbiology · 2022Article
- In-depth Analysis of ISFrontiers in microbiology · 2022Article
- Intragenic Distribution of ISMicrobiology spectrum · 2021Article
- EvoLSTM: context-dependent models of sequence evolution using a sequence-to-sequence LSTM.Bioinformatics (Oxford, England) · 2020Article
- Transposition mechanism, molecular characterization and evolution of IS6110, the specific evolutionary marker of Mycobacterium tuberculosis complex.Molecular biology reports · 2017Review
- Genetic diversity of the Mycobacterium tuberculosis Beijing family based on multiple genotyping profiles.Epidemiology and infection · 2016Article
- ISMapper: identifying transposase insertion sites in bacterial genomes from short read sequence data.BMC genomics · 2015Article
- Analysis of IS6110 insertion sites provide a glimpse into genome evolution of Mycobacterium tuberculosis.Scientific reports · 2015Article
- Article
- Global study of IS6110 in a successful Mycobacterium tuberculosis strain: clues for deciphering its behavior and for its rapid detection.Journal of clinical microbiology · 2013Article
- Simple multiplex PCR assay for identification of Beijing family Mycobacterium tuberculosis isolates with a lineage-specific mutation in Rv0679c.Journal of clinical microbiology · 2013Article
- Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype.BMC genomics · 2013Article
- Characterization of microevolution events in Mycobacterium tuberculosis strains involved in recent transmission clusters.Journal of clinical microbiology · 2011Article
- Sublineages of Beijing Strain of Mycobacterium tuberculosis in Sri Lanka.Indian journal of microbiology · 2011Article
- Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden.PloS one · 2011Article
- Novel hot spot of IS6110 insertion in Mycobacterium tuberculosis.Journal of clinical microbiology · 2010Article
- Polymorphic exact tandem repeat A (PETRA): a newly defined lineage of mycobacterium tuberculosis in israel originating predominantly in Sub-Saharan Africa.Journal of clinical microbiology · 2009Article
- Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region.BMC evolutionary biology · 2009Article
- Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain.BMC pulmonary medicine · 2009Article
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Authors and funding
3 authors.
Funding
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Abstract
A widely distributed strain designated 210 was identified in a study of the diversity of Mycobacterium tuberculosis DNA fingerprints from three geographically separate states in the United States. This strain is characterized by a 21-band fingerprint pattern when probed with IS6110, and the pattern is similar to that displayed by strains designated W. Intracellular growth of strain 210 isolates in human macrophages is significantly faster than that of isolates from other clusters or nonclustered isolates. The purpose of this study was to identify the sites of IS6110 insertions in strain 210 and compare these to IS6110 insertion sites in strain W. Our hypothesis is that an IS6110 insertion site(s) could possibly be responsible for a strain's increased capacity for transmission and/or replication. In this report, the insertion sites in strains 210 and W are described and referenced to their location in the M. tuberculosis H37Rv genome sequence. The W and 210 strains have 17 identical sites of IS6110 insertion and additional sequence not found in H37Rv but present in other clinical isolates. The IS6110 insertion site in the 36-bp direct repeat (DR) region of strains 210 and W has 15 spacers in the left flanking region. The DR region on the right side of IS6110 has been deleted. Five sites of insertion in strain 210 not found in strain W are described, as well as two unique sites in strain W. One copy of IS6110 was found to reside 55 bp in the ctpD gene. This gene is expressed, indicating that IS6110 can provide a promoter sequence for the transcription of genes.
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